PMID- 12086317
OWN - NLM
STAT- MEDLINE
DCOM- 20020725
LR  - 20190916
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 184
DP  - 2001 Dec
TI  - Host-tumor interactions during the regression of a rat histiocytoma, AK-5.
PG  - 244-57
AB  - An efficient immune response comprises a highly intricate, integrated circuitry 
      involving both the cellular and the humoral arms of the immune system of the host 
      interacting with the rapidly proliferating microcosm of the tumor The mechanism 
      of tumor rejection involving multiple arms of the immune system was reviewed in a 
      spontaneously regressing rat histiocytoma, AK-5, an autologous tumor-host system. 
      Intraperitoneal tumor transplantation leads to death in all animals, whereas 
      subcutaneously (s.c.) transplanted tumor undergoes regression in 70% of animals. 
      Regression of the tumor occurs by both apoptosis and necrosis, and natural killer 
      (NK) cells were identified as the chief effectors mediating tumor cell death in 
      vivo. A type 1 helper T cell (Th1)-driven cytokine cascade played a crucial role 
      in enhancing cellular functions at the tumor site and obtaining a sufficient 
      immune response for tumor rejection. The s.c. tumor-bearing hosts were shown to 
      produce a factor which induced apoptosis in tumor cells, mediating tumor 
      rejection. This review emphasizes the daunting complexities and interesting 
      liaisons between the host immune system and the tumor, highlighting the work from 
      our laboratory, and stressing that it is the interaction of several factors in 
      concert or antagonizing each other that is responsible for the spontaneous 
      regression of a tumor.
FAU - Khar, A
AU  - Khar A
AD  - Centre for Cellular & Molecular Biology, Hyderabad, India. khar@ccmb.ap.nic.in
FAU - Anjum, R
AU  - Anjum R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Cytokines)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Adjuvants, Immunologic
MH  - Animals
MH  - Antibody Formation/immunology
MH  - Cell Death
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Histiocytoma, Benign Fibrous/*immunology
MH  - Humans
MH  - Immunity, Cellular/immunology
MH  - Killer Cells, Natural/immunology
MH  - Lymphocyte Activation/immunology
MH  - Macrophages/immunology
MH  - Neoplasm Regression, Spontaneous/*immunology
MH  - Rats
MH  - Skin Neoplasms/*immunology
MH  - fas Receptor/biosynthesis/immunology
RF  - 107
EDAT- 2002/06/28 10:00
MHDA- 2002/07/26 10:01
CRDT- 2002/06/28 10:00
PHST- 2002/06/28 10:00 [pubmed]
PHST- 2002/07/26 10:01 [medline]
PHST- 2002/06/28 10:00 [entrez]
AID - 10.1034/j.1600-065x.2001.1840122.x [doi]
PST - ppublish
SO  - Immunol Rev. 2001 Dec;184:244-57. doi: 10.1034/j.1600-065x.2001.1840122.x.