PMID- 12086747
OWN - NLM
STAT- MEDLINE
DCOM- 20020730
LR  - 20220409
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 25
IP  - 6
DP  - 2002 Jun
TI  - Exercise: a behavioral intervention to enhance brain health and plasticity.
PG  - 295-301
AB  - Extensive research on humans suggests that exercise could have benefits for 
      overall health and cognitive function, particularly in later life. Recent studies 
      using animal models have been directed towards understanding the neurobiological 
      bases of these benefits. It is now clear that voluntary exercise can increase 
      levels of brain-derived neurotrophic factor (BDNF) and other growth factors, 
      stimulate neurogenesis, increase resistance to brain insult and improve learning 
      and mental performance. Recently, high-density oligonucleotide microarray 
      analysis has demonstrated that, in addition to increasing levels of BDNF, 
      exercise mobilizes gene expression profiles that would be predicted to benefit 
      brain plasticity processes. Thus, exercise could provide a simple means to 
      maintain brain function and promote brain plasticity.
FAU - Cotman, Carl W
AU  - Cotman CW
AD  - Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, 
      University of California, Irvine, CA 92697-4540, USA. cwcotman@uci.edu
FAU - Berchtold, Nicole C
AU  - Berchtold NC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogens)
RN  - 0 (RNA, Messenger)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/analysis/*genetics
MH  - Cognition/physiology
MH  - Estrogens/deficiency/physiology
MH  - *Exercise
MH  - Gene Expression
MH  - Hippocampus/*chemistry/metabolism/physiology
MH  - Humans
MH  - In Situ Hybridization
MH  - Learning/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Oligonucleotide Array Sequence Analysis
MH  - *Physical Conditioning, Animal
MH  - RNA, Messenger/analysis
MH  - gamma-Aminobutyric Acid/metabolism
RF  - 70
EDAT- 2002/06/28 10:00
MHDA- 2002/07/31 10:01
CRDT- 2002/06/28 10:00
PHST- 2002/06/28 10:00 [pubmed]
PHST- 2002/07/31 10:01 [medline]
PHST- 2002/06/28 10:00 [entrez]
AID - S0166-2236(02)02143-4 [pii]
AID - 10.1016/s0166-2236(02)02143-4 [doi]
PST - ppublish
SO  - Trends Neurosci. 2002 Jun;25(6):295-301. doi: 10.1016/s0166-2236(02)02143-4.