PMID- 12088209
OWN - NLM
STAT- MEDLINE
DCOM- 20020711
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 56 Spec No 1
DP  - 2001 Mar
TI  - Caloric restriction mimetics: metabolic interventions.
PG  - 20-33
AB  - Caloric restriction (CR) retards diseases and aging in laboratory rodents and is 
      now being tested in nonhuman primates. One way to apply these findings to human 
      health is to identify and test agents that may mimic critical actions of CR. 
      Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved 
      glucoregulation, for which candidate metabolic mimics exist. It was recommended 
      that studies on oxidative stress should emphasize mitochondrial function and to 
      test the efficacy of nitrone and other antioxidants in mimicking CR's effects. 
      Studies should also focus on the long-term effects of compounds known to lower 
      circulating glucose and insulin concentrations or to increase insulin 
      sensitivity. Also, four other developing areas were identified: intermediary 
      metabolism, response to infection, stress responses, and source of dietary fat. 
      These areas are important because either they hold promise for the discovery of 
      new mimetics or they need to be explored prior to initiation of CR trials in 
      humans. Other recommendations were that transgenic approaches and adult-onset CR 
      should be emphasized in future studies.
FAU - Weindruch, R
AU  - Weindruch R
AD  - Department of Medicine, University of Wisconsin, VA Hospital, Madison 53705-2286, 
      USA. rhweindr@facstaff.wisc.edu
FAU - Keenan, K P
AU  - Keenan KP
FAU - Carney, J M
AU  - Carney JM
FAU - Fernandes, G
AU  - Fernandes G
FAU - Feuers, R J
AU  - Feuers RJ
FAU - Floyd, R A
AU  - Floyd RA
FAU - Halter, J B
AU  - Halter JB
FAU - Ramsey, J J
AU  - Ramsey JJ
FAU - Richardson, A
AU  - Richardson A
FAU - Roth, G S
AU  - Roth GS
FAU - Spindler, S R
AU  - Spindler SR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Blood Glucose/*metabolism
MH  - *Energy Intake
MH  - Humans
MH  - Insulin/physiology
MH  - Mitochondria/physiology
MH  - Oxidative Stress/*physiology
RF  - 162
EDAT- 2002/06/29 10:00
MHDA- 2002/07/12 10:01
CRDT- 2002/06/29 10:00
PHST- 2002/06/29 10:00 [pubmed]
PHST- 2002/07/12 10:01 [medline]
PHST- 2002/06/29 10:00 [entrez]
AID - 10.1093/gerona/56.suppl_1.20 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2001 Mar;56 Spec No 1:20-33. doi: 
      10.1093/gerona/56.suppl_1.20.