PMID- 12088713
OWN - NLM
STAT- MEDLINE
DCOM- 20020826
LR  - 20220321
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 113
IP  - 7
DP  - 2002 Jul
TI  - Variation in the response to transcranial magnetic brain stimulation in the 
      general population.
PG  - 1165-71
AB  - OBJECTIVES: The aim of this study is to describe the variability and other 
      characteristics of the motor evoked potential (MEP) to transcranial magnetic 
      stimulation (TMS) in a large database. METHODS: One hundred fifty one subjects, 
      including 17 sib pairs, free of neurological or psychiatric disease and on no 
      neuroactive medications were studied with uniform techniques. Nineteen were 
      studied on 3 occasions. Measures included MEP threshold (N=141) during rest and 
      voluntary muscle activation and the response to paired TMS (subthreshold 
      conditioning stimulus) at interstimulus intervals (ISIs) of 3, 4, 10, and 15ms 
      (N=53). RESULTS: There was a large variability in all the measures. Approximately 
      40-50% of this appeared to come from within-subjects variation or experimental 
      error. The MEP threshold data were skewed downward, but normalized with log 
      transformation. The paired-pulse ratios (conditioned/unconditioned MEP) were 
      normally distributed except those from the 3ms ISI which had no lower tail and 
      could not be normalized. There were subjects showing inhibition and others 
      showing facilitation at all ISIs. There were no correlations in any of the data 
      with age or sex, but MEP thresholds were highly correlated within sibs. 
      CONCLUSIONS: These data should be useful for planning, analyzing, and 
      interpreting TMS studies in healthy and patient populations.
FAU - Wassermann, Eric M
AU  - Wassermann EM
AD  - Brain Stimulation Unit, National Institute of Neurological Disorders and Stroke, 
      National Institutes of Health, Bethesda, MD, USA. wassermanne@ninds.nih.gov
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - Brain/*physiology
MH  - Conditioning, Psychological/physiology
MH  - Databases, Factual
MH  - *Electromagnetic Fields
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Individuality
MH  - Male
MH  - Middle Aged
EDAT- 2002/06/29 10:00
MHDA- 2002/08/27 10:01
CRDT- 2002/06/29 10:00
PHST- 2002/06/29 10:00 [pubmed]
PHST- 2002/08/27 10:01 [medline]
PHST- 2002/06/29 10:00 [entrez]
AID - S138824570200144X [pii]
AID - 10.1016/s1388-2457(02)00144-x [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2002 Jul;113(7):1165-71. doi: 10.1016/s1388-2457(02)00144-x.