PMID- 12088754
OWN - NLM
STAT- MEDLINE
DCOM- 20020903
LR  - 20190712
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 112
IP  - 4
DP  - 2002
TI  - Injection of brain-derived neurotrophic factor in the rostral ventrolateral 
      medulla increases arterial blood pressure in anaesthetized rats.
PG  - 967-75
AB  - Brain-derived neurotrophic factor (BDNF) is a unique neurotrophin which not only 
      supports the development of neurons but also modulates the synaptic activity in a 
      number of neuronal systems. BDNF is synthesized in neurons, anterogradely 
      transported and released from nerve terminals and exerts acute effects on 
      synaptic transmission in both peripheral and central nervous systems. Previous 
      studies have shown that BDNF is distributed in several groups of neurons in the 
      brain stem which regulate cardiovascular functions. Here we showed that injection 
      of BDNF (40-400 ng/100 nl) into the rostral ventrolateral medulla resulted in a 
      significant increase in arterial blood pressure (Delta35.5+/-3.5 mmHg) in rats. 
      The duration of change in blood pressure was 145+/-40 s with a latency of 3-5 s. 
      There was no significant effect on the heart rate. The injection of glutamate as 
      a positive control also triggered an increase in blood pressure. Injection of 
      phosphate-buffered saline as a control or the same amount of nerve growth factor 
      did not cause significant changes in blood pressure in different preparations. 
      Immunohistochemistry showed that the nerve terminals immunoreactive for BDNF were 
      localized in several brain stem regions and terminate around spinal projection 
      neurons in the rostral ventrolateral medulla. Neurons in the rostral 
      ventrolateral medulla can uptake exogenous BDNF and express the high affinity 
      receptor trkB. From these results we suggest that BNDF in the medulla may play a 
      role in the regulation of blood pressure.
FAU - Wang, H
AU  - Wang H
AD  - Department of Human Physiology and Centre for Neuroscience, Flinders University, 
      GPO Box 2100, Adelaide, SA 5001, Australia.
FAU - Zhou, X-F
AU  - Zhou XF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Amidines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Recombinant Proteins)
RN  - 0 (diamidino compound 253-50)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Amidines
MH  - Animals
MH  - *Blood Pressure/drug effects
MH  - Brain-Derived Neurotrophic Factor/pharmacology/*physiology
MH  - Fluorescent Dyes
MH  - Immunohistochemistry
MH  - Male
MH  - Medulla Oblongata/chemistry/drug effects/*physiology
MH  - Microinjections
MH  - Rats
MH  - Rats, Inbred WKY
MH  - Receptor, trkB/*analysis/drug effects
MH  - Recombinant Proteins/pharmacology
EDAT- 2002/06/29 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/06/29 10:00
PHST- 2002/06/29 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/06/29 10:00 [entrez]
AID - S0306452202000854 [pii]
AID - 10.1016/s0306-4522(02)00085-4 [doi]
PST - ppublish
SO  - Neuroscience. 2002;112(4):967-75. doi: 10.1016/s0306-4522(02)00085-4.