PMID- 12089692
OWN - NLM
STAT- MEDLINE
DCOM- 20020724
LR  - 20211203
IS  - 0278-2391 (Print)
IS  - 0278-2391 (Linking)
VI  - 60
IP  - 7
DP  - 2002 Jul
TI  - Analysis of human leukocyte antigens in patients with internal derangement of the 
      temporomandibular joint.
PG  - 778-83
AB  - PURPOSE: Spondyloarthropathy includes the subcategory of reactive arthritis 
      (ReA). Spondyloarthropathies are commonly associated with certain human leukocyte 
      antigen (HLA) alleles. Because we identified bacteria associated with ReA within 
      the temporomandibular joint (TMJ), we now evaluate the frequency of HLA alleles 
      in patients with TMJ pathology. PATIENTS AND METHODS: HLA typing of 129 patients 
      (121 females and 8 males) performed by standard microcytotoxicity technique. 
      Thirty patients had only class I (HLA-A and -B loci) evaluated. Ninety-nine 
      patients had both class I and class II (HLA-DR loci) evaluated. Identification of 
      alleles at the C locus was not performed. The antigenic frequency in the study 
      group was compared to US white control subjects using a 2-tailed Fisher's exact 
      test with a Bonferroni multiple comparison adjustment. RESULTS: The following 
      class I HLA alleles, -A1 (32%), -A2 (50%), -A3 (33%), -B7 (23%), -B14 (14%), -B35 
      (20%), and -B44 (36%), including the B7 cross-reactive group (CREG) (49%) and 
      class II alleles -DR1 (25%) and -DR4 (34%), were found to have an increased 
      frequency in our patient group. CONCLUSIONS: Our study shows an increased 
      frequency of several alleles that have been previously associated with 
      arthropathy, and the alleles of the B7 CREG, in patients with TMJ pathology. 
      Patients with these alleles may have an increased risk for the development of 
      internal derangement of the TMJ as a consequence of the bacterial/infectious 
      agents and host interactions with the subsequent cytokine/inflammatory response 
      being influenced by their HLA phenotype.
CI  - Copyright 2002 American Association of Oral and Maxillofacial Surgeons
FAU - Henry, Charles H
AU  - Henry CH
AD  - Baylor University Medical Center Transplantation Laboratory, Dallas, TX, USA. 
      chenry@pol.net
FAU - Nikaein, Afzal
AU  - Nikaein A
FAU - Wolford, Larry M
AU  - Wolford LM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American 
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A1 Antigen)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B14 Antigen)
RN  - 0 (HLA-B35 Antigen)
RN  - 0 (HLA-B44 Antigen)
RN  - 0 (HLA-B7 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR1 Antigen)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (PHB2 protein, human)
RN  - 0 (Prohibitins)
SB  - IM
MH  - Alleles
MH  - Arthritis, Reactive/immunology
MH  - Case-Control Studies
MH  - Chromosome Mapping
MH  - Cross Reactions
MH  - Disease Susceptibility
MH  - Female
MH  - HLA Antigens/*analysis
MH  - HLA-A Antigens/analysis
MH  - HLA-A1 Antigen/analysis
MH  - HLA-A2 Antigen/analysis
MH  - HLA-A3 Antigen/analysis
MH  - HLA-B Antigens/analysis
MH  - HLA-B14 Antigen
MH  - HLA-B35 Antigen/analysis
MH  - HLA-B44 Antigen
MH  - HLA-B7 Antigen/analysis
MH  - HLA-DR Antigens/analysis
MH  - HLA-DR1 Antigen/analysis
MH  - HLA-DR4 Antigen/analysis
MH  - Humans
MH  - Joint Dislocations/*immunology
MH  - Likelihood Functions
MH  - Male
MH  - Prohibitins
MH  - Statistics as Topic
MH  - Temporomandibular Joint Disc/*immunology
MH  - Temporomandibular Joint Disorders/immunology
EDAT- 2002/06/29 10:00
MHDA- 2002/07/26 10:01
CRDT- 2002/06/29 10:00
PHST- 2002/06/29 10:00 [pubmed]
PHST- 2002/07/26 10:01 [medline]
PHST- 2002/06/29 10:00 [entrez]
AID - S0278239102000113 [pii]
AID - 10.1053/joms.2002.33245 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2002 Jul;60(7):778-83. doi: 10.1053/joms.2002.33245.