PMID- 12090726
OWN - NLM
STAT- MEDLINE
DCOM- 20030114
LR  - 20051116
IS  - 1472-4472 (Print)
IS  - 1472-4472 (Linking)
VI  - 3
IP  - 4
DP  - 2002 Apr
TI  - Angiotensin II as a pro-inflammatory mediator.
PG  - 569-77
AB  - Angiotensin II (Ang II), the most important component of the renin-angiotensin 
      system, is usually associated with hypertension and renal failure. Through its 
      pro-inflammatory actions, it also plays an important role in each step of the 
      development of atherosclerotic plaques and plaque rupture. Ang II stimulates the 
      expression of nuclear factor-kappaB (NFkappaB), a transcription factor which 
      regulates gene expression of inflammatory cytokines such as interleukin-6 (IL-6) 
      and monocyte chemoattractant protein-1 (MCP-1). Ang II type 1 receptors (AT1) and 
      angiotensin converting enzyme (ACE) are dramatically increased in atherosclerotic 
      plaques, particularly in monocytes at the fibrous cap. Thus, in multiple ways, 
      Ang II is a critical factor in atherosclerotic plaque formation, inflammation and 
      plaque stability. ACE inhibitors and AT1R inhibitors could therefore be 
      appropriate therapeutic agents in the treatment of atherosclerosis.
FAU - Phillips, M Ian
AU  - Phillips MI
AD  - Department of Physiology, College of Medicine, University of Florida, Gainesville 
      32610, USA. MIP@ufl.edu
FAU - Kagiyama, Shuntaro
AU  - Kagiyama S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Investig Drugs
JT  - Current opinion in investigational drugs (London, England : 2000)
JID - 100965718
RN  - 0 (Cytokines)
RN  - 0 (Growth Substances)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Receptors, Angiotensin)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Angiotensin II/*physiology
MH  - Animals
MH  - Arteriosclerosis/etiology/metabolism/physiopathology
MH  - Cell Adhesion
MH  - Chemotaxis
MH  - Cytokines/metabolism
MH  - Endothelium, Vascular/metabolism/physiology
MH  - Growth Substances/physiology
MH  - Humans
MH  - Inflammation/metabolism
MH  - Macrophages/metabolism/physiology
MH  - Muscle, Smooth, Vascular/metabolism/pathology/physiology
MH  - NF-kappa B/metabolism
MH  - Receptor, Angiotensin, Type 1
MH  - Receptors, Angiotensin/metabolism
MH  - Renin/metabolism
RF  - 90
EDAT- 2002/07/02 10:00
MHDA- 2003/01/15 04:00
CRDT- 2002/07/02 10:00
PHST- 2002/07/02 10:00 [pubmed]
PHST- 2003/01/15 04:00 [medline]
PHST- 2002/07/02 10:00 [entrez]
PST - ppublish
SO  - Curr Opin Investig Drugs. 2002 Apr;3(4):569-77.