PMID- 12091558
OWN - NLM
STAT- MEDLINE
DCOM- 20020906
LR  - 20220316
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 88
IP  - 1
DP  - 2002 Jul
TI  - Effect of volitional inhibition on cortical inhibitory mechanisms.
PG  - 333-8
AB  - To investigate the effect of volitional inhibition on cortical inhibitory 
      mechanisms, we performed transcranial magnetic stimulation (TMS) studies with a 
      Go/NoGo reaction task in seven healthy subjects. Subjects were asked to extend 
      their right index finger only after Go, but to remain relaxed after NoGo. Single- 
      and paired-pulse TMS were triggered at the average reaction time for the Go 
      response in each subject after Go or NoGo cues. Motor evoked potentials were 
      recorded in the extensor indicis proprius (EIP) and abductor digiti minimi (ADM) 
      muscles of right hand. Paired-pulse TMS with subthreshold conditioning stimuli at 
      interstimulus intervals (ISIs) of 2 ms [short intracortical inhibition (SICI)] 
      and 15 ms [intracortical facilitation (ICF)] and that with suprathreshold 
      conditioning stimuli at ISI of 80 ms [long intracortical inhibition (LICI)] were 
      performed in both Go/NoGo and control conditions. Inhibition of SICI was enhanced 
      in both EIP and ADM after NoGo and was reduced only in EIP after Go. Inhibition 
      of LICI was reduced in both muscles during both conditions, while ICF was not 
      altered. The present results demonstrate that volitional inhibition enhances SICI 
      but reduces LICI nonselectively. These results suggest that these two inhibitory 
      mechanisms act differently during execution and suppression of voluntary 
      movements.
FAU - Sohn, Young H
AU  - Sohn YH
AD  - Human Motor Control Section, National Institute of Neurological Disorders and 
      Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Wiltz, Katy
AU  - Wiltz K
FAU - Hallett, Mark
AU  - Hallett M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adult
MH  - Differential Threshold
MH  - Electric Stimulation
MH  - Electromyography
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Hand
MH  - Humans
MH  - Magnetics
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Movement/physiology
MH  - Muscle, Skeletal/physiology
MH  - Neural Inhibition/*physiology
MH  - Reaction Time
MH  - *Volition
EDAT- 2002/07/02 10:00
MHDA- 2002/09/07 10:01
CRDT- 2002/07/02 10:00
PHST- 2002/07/02 10:00 [pubmed]
PHST- 2002/09/07 10:01 [medline]
PHST- 2002/07/02 10:00 [entrez]
AID - 10.1152/jn.2002.88.1.333 [doi]
PST - ppublish
SO  - J Neurophysiol. 2002 Jul;88(1):333-8. doi: 10.1152/jn.2002.88.1.333.