PMID- 12091576
OWN - NLM
STAT- MEDLINE
DCOM- 20020906
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 88
IP  - 1
DP  - 2002 Jul
TI  - Short- and long-term plasticity of the perforant path synapse in hippocampal area 
      CA3.
PG  - 528-33
AB  - The direct perforant path (PP) projection to CA3 is a major source of cortical 
      input to the hippocampal region, yet relatively little is known about the basic 
      properties of physiology and plasticity in this pathway. We tested whether PP 
      long-term potentiation (LTP) in CA3 possesses the Hebbian property of 
      associativity; i.e., whether the firing of fibers of different orders can induce 
      PP LTP. We stimulated PP with weak trains of high-frequency stimulation (HFS), 
      which by itself was below the threshold for LTP induction. The identical HFS was 
      effective in inducing LTP when the mossy fiber pathway (MF) was activated 
      simultaneously, thus demonstrating associative plasticity between the two 
      pathways. We also demonstrated associative LTP between PP and recurrent 
      collateral fibers (RC). PP LTP was blocked by the N-methyl-D-aspartate receptor 
      (NMDAR) antagonist 2-amino-5-phosphonovaleric acid in both the associative and 
      homosynaptic induction conditions. Neither MF nor RC fiber HFS alone resulted in 
      permanent changes in PP field excitatory postsynaptic potential (fEPSP) 
      amplitude. However, HFS delivered to either MF or RC alone led to transient 
      heterosynaptic depression of the PP fEPSP. Our results support the conceptual 
      framework that regards CA3 as an autoassociative memory network in which 
      efficient retrieval of previously stored activity patterns is mediated by 
      associative plasticity of the PP synapse.
FAU - McMahon, David B T
AU  - McMahon DB
AD  - Department of Neuroscience and Center for the Neural Basis of Cognition, 
      University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. 
      mcmahon@cnbc.cmu.edu
FAU - Barrionuevo, German
AU  - Barrionuevo G
LA  - eng
GR  - NS242882/NS/NINDS NIH HHS/United States
GR  - T32 NS-07433/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 36B82AMQ7N (Naloxone)
SB  - IM
MH  - Animals
MH  - Electric Stimulation/methods
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Hippocampus/*physiology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/physiology
MH  - Male
MH  - Mossy Fibers, Hippocampal/physiology
MH  - Naloxone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Neuronal Plasticity/*physiology
MH  - Perforant Pathway/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Synapses/drug effects/*physiology
MH  - Time Factors
EDAT- 2002/07/02 10:00
MHDA- 2002/09/07 10:01
CRDT- 2002/07/02 10:00
PHST- 2002/07/02 10:00 [pubmed]
PHST- 2002/09/07 10:01 [medline]
PHST- 2002/07/02 10:00 [entrez]
AID - 10.1152/jn.2002.88.1.528 [doi]
PST - ppublish
SO  - J Neurophysiol. 2002 Jul;88(1):528-33. doi: 10.1152/jn.2002.88.1.528.