PMID- 12091857
OWN - NLM
STAT- MEDLINE
DCOM- 20020807
LR  - 20191210
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 141
IP  - 1
DP  - 2002 Jul
TI  - Premature pubarche in girls is associated with functional adrenal but not ovarian 
      hyperandrogenism.
PG  - 91-8
AB  - OBJECTIVE: We hypothesized that there would be evidence of functional ovarian 
      hyperandrogenism in girls with premature pubarche (PP) at diagnosis. METHODS: 
      White girls <8 years of age and black girls <6 years with PP (n = 15) were 
      studied. Prepubertal girls (n = 13; 5.3-10.9 years) and early pubertal girls (n = 
      8) served as control subjects. The biochemical marker for functional ovarian 
      hyperandrogenism was the 17-hydroxyprogesterone (17-OHP), androstenedione (AD), 
      and estradiol (E2) response to subcutaneous leuprolide during adrenal suppression 
      with dexamethasone. This was studied in girls with PP and in control subjects. 
      RESULTS: ACTH stimulated 17-hydroxypregnenolone (17-OH Preg), 
      dehydroepiandrosterone (DHEA), and AD levels, and 17-OH Preg:17-OHP and DHEA:AD 
      ratios were significantly higher in girls with PP than in prepubertal control 
      subjects (n = 18) (P < or =.003). The ovarian response to leuprolide stimulation 
      was comparable in girls with PP and prepubertal control subjects, but the 
      response in prepubertal study subjects was significantly lower than in pubertal 
      control subjects (P =.016 for Delta17-OHP, P =.001 for DeltaAD, and P =.026 for 
      DeltaE2). CONCLUSIONS: Contrary to the hypothesis, PP in girls was not associated 
      with prepubertal evidence of ovarian hyperandrogenism but was associated with 
      functional adrenal hyperandrogenism.
FAU - Mathew, Revi P
AU  - Mathew RP
AD  - Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232, USA.
FAU - Najjar, Jennifer L
AU  - Najjar JL
FAU - Lorenz, Rodney A
AU  - Lorenz RA
FAU - Mayes, Darrel E
AU  - Mayes DE
FAU - Russell, William E
AU  - Russell WE
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Biomarkers)
RN  - 0 (Steroids)
RN  - 409J2J96VR (Androstenedione)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 68-96-2 (17-alpha-Hydroxyprogesterone)
SB  - IM
MH  - 17-alpha-Hydroxyprogesterone/blood
MH  - Adrenal Cortex/*metabolism
MH  - Androstenedione/blood
MH  - Biomarkers
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dehydroepiandrosterone/blood
MH  - Estradiol/blood
MH  - Female
MH  - Hirsutism/*etiology/metabolism
MH  - Humans
MH  - Hyperandrogenism/*etiology/metabolism
MH  - Immunoenzyme Techniques
MH  - Ovary/*metabolism
MH  - Statistics, Nonparametric
MH  - Steroids/*blood
EDAT- 2002/07/02 10:00
MHDA- 2002/08/08 10:01
CRDT- 2002/07/02 10:00
PHST- 2002/07/02 10:00 [pubmed]
PHST- 2002/08/08 10:01 [medline]
PHST- 2002/07/02 10:00 [entrez]
AID - S0022-3476(02)00044-6 [pii]
AID - 10.1067/mpd.2002.125492 [doi]
PST - ppublish
SO  - J Pediatr. 2002 Jul;141(1):91-8. doi: 10.1067/mpd.2002.125492.