PMID- 12093587
OWN - NLM
STAT- MEDLINE
DCOM- 20020807
LR  - 20191210
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 27
IP  - 2
DP  - 2002 Aug
TI  - Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to 
      cues previously associated with footshock.
PG  - 133-42
AB  - This study examined the effects of footshock stress and re-exposure to cues 
      previously associated with footshock on expression of brain-derived neurotrophic 
      factor (BDNF) mRNA in the hippocampus of male rats. Exposure to twenty 0.5-s 
      0.4-mA footshocks co-terminating with 70 dB, 5-s long pure tones over 60 min 
      decreased dentate gyrus BDNF mRNA by 21.5%. Baseline BDNF mRNA levels returned to 
      normal by two days after footshock exposure. Re-exposure for 60 min to the 
      chamber and tones previously paired with 0.4 mA footshock decreased BDNF mRNA by 
      12%. Re-exposure to the conditioning chamber and tones previously paired with 0.6 
      mA footshock over 60 min decreased BDNF mRNA by 20.8%. The data suggest that 
      psychological, as well as unconditioned physical stress, can decrease hippocampal 
      BDNF mRNA. Possible implications for stress-related and other neuropsychiatric 
      disorders associated with deficits in hippocampal function and volume, such as 
      depression, post-traumatic stress disorder, and Alzheimer's Disease, are 
      discussed.
FAU - Rasmusson, Ann M
AU  - Rasmusson AM
AD  - VA National Center for PTSD, Clinical Neuroscience Division, West Haven, CT, USA. 
      ann.rasmusson@yale.edu
FAU - Shi, Libin
AU  - Shi L
FAU - Duman, Ronald
AU  - Duman R
LA  - eng
GR  - 2P01MH25642/MH/NIMH NIH HHS/United States
GR  - MH45481/MH/NIMH NIH HHS/United States
GR  - MH53199/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Conditioning, Psychological/*physiology
MH  - *Cues
MH  - Dentate Gyrus/*metabolism/pathology/physiopathology
MH  - Depression/metabolism/pathology/physiopathology
MH  - Down-Regulation/*physiology
MH  - Electric Stimulation/adverse effects
MH  - Fear/physiology
MH  - Male
MH  - Neuronal Plasticity/physiology
MH  - Neurons/metabolism/pathology
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress Disorders, Post-Traumatic/metabolism/pathology/physiopathology
MH  - Stress, Psychological/*metabolism/pathology/physiopathology
EDAT- 2002/07/03 10:00
MHDA- 2002/08/08 10:01
CRDT- 2002/07/03 10:00
PHST- 2002/07/03 10:00 [pubmed]
PHST- 2002/08/08 10:01 [medline]
PHST- 2002/07/03 10:00 [entrez]
AID - S0893133X02002865 [pii]
AID - 10.1016/S0893-133X(02)00286-5 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2002 Aug;27(2):133-42. doi: 
      10.1016/S0893-133X(02)00286-5.