PMID- 12097695
OWN - NLM
STAT- MEDLINE
DCOM- 20020726
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 132
IP  - 7
DP  - 2002 Jul
TI  - Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor 
      growth and metastasis in Lewis lung carcinoma-bearing mice.
PG  - 2069-75
AB  - I examined the effects of carp oil, oleic acid, linoleic acid and linolenic acid 
      on tumor growth and metastasis to the liver in mice implanted intrasplenically 
      with highly metastatic Lewis lung carcinoma (LLC) tumors. Carp oil (0.1 or 0.2 mL 
      per mouse) significantly reduced tumor growth and metastasis to the liver. Carp 
      oil at 100 or 1000 mg/L inhibited the DNA synthesis in LLC cells, the 
      capillary-like tube formation of human dermal microvascular endothelial cells 
      (HMVEC) at 1000 mg/L and the adherence of LLC cells to HMVEC at 10 to 1000 mg/L 
      (in vitro). Carp oil (0.2 mL per mouse) inhibited the angiogenesis induced by 
      Matrigel supplemented with vascular endothelial growth factor (VEGF) and heparin 
      (in vivo). Antitumor and antimetastatic actions of carp oil might be partly 
      attributable to the inhibition of DNA synthesis in LLC cells and angiogenesis 
      through the inhibition of the adherence of LLC cells to the microvascular 
      endothelium. Oleic acid (0.1 or 0.2 mL per mouse) significantly inhibited the 
      metastasis to the liver, but it had no effect on the primary solid-tumor growth. 
      Oleic acid inhibited the angiogenesis in both in vitro and in vivo models. Oleic 
      acid at 1000 micromol/L inhibited the DNA synthesis in LLC cells but did not 
      affect the DNA synthesis in HMVEC. These inhibitory actions of oleic acid may be 
      attributable to the inhibition of angiogenesis induced by the tumor. Linoleic 
      acid and linolenic acid had no effect on tumor growth or metastasis to the liver.
FAU - Kimura, Yoshiyuki
AU  - Kimura Y
AD  - Second Department of Medical Biochemistry, School of Medicine, Ehime University, 
      Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan. yokim@m.ehime-u.ac.jp
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Combinations)
RN  - 0 (Fish Oils)
RN  - 0 (Laminin)
RN  - 0 (Proteoglycans)
RN  - 0RBV727H71 (alpha-Linolenic Acid)
RN  - 119978-18-6 (matrigel)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - 9007-34-5 (Collagen)
RN  - 9007-49-2 (DNA)
RN  - 9KJL21T0QJ (Linoleic Acid)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/pharmacology
MH  - Blood Cell Count
MH  - Body Weight/drug effects
MH  - Carcinoma, Lewis Lung/blood supply/*pathology/secondary
MH  - *Carps
MH  - Collagen/pharmacology
MH  - DNA/biosynthesis
MH  - Drug Combinations
MH  - Energy Intake/drug effects
MH  - Fish Oils/*pharmacology
MH  - Humans
MH  - Laminin/pharmacology
MH  - Linoleic Acid/pharmacology
MH  - Lung Neoplasms/blood supply/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasm Metastasis/prevention & control
MH  - Neovascularization, Pathologic/prevention & control
MH  - Oleic Acid/*pharmacology
MH  - Organ Size/drug effects
MH  - Proteoglycans/pharmacology
MH  - Tumor Cells, Cultured
MH  - alpha-Linolenic Acid/pharmacology
EDAT- 2002/07/05 10:00
MHDA- 2002/07/27 10:01
CRDT- 2002/07/05 10:00
PHST- 2002/07/05 10:00 [pubmed]
PHST- 2002/07/27 10:01 [medline]
PHST- 2002/07/05 10:00 [entrez]
AID - 10.1093/jn/132.7.2069 [doi]
PST - ppublish
SO  - J Nutr. 2002 Jul;132(7):2069-75. doi: 10.1093/jn/132.7.2069.