PMID- 12098525
OWN - NLM
STAT- MEDLINE
DCOM- 20020827
LR  - 20190901
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 127
IP  - 1-2
DP  - 2002 Jun 25
TI  - A contribution to the chemical profiling of 3,4-methylenedioxymethamphetamine 
      (MDMA) tablets.
PG  - 1-44
AB  - A profiling method for the identification of impurities found in seized 
      3,4-methylenedioxymethamphetamine (MDMA) tablets is presented. Impurities of 
      interest are extracted from an alkaline solution (pH 12.8) by diethyl ether and 
      submitted to gas chromatography (GC)-mass spectrometry (MS) analyses. 
      Identification of impurities is performed by electron impact ionization (Ei) mass 
      spectrometry and confirmation by positive chemical ionization (Ci+) MS or, when 
      possible, MS/MS (MS(2)). Repeat extractions of the same sample give an average 
      relative standard deviation (R.S.D.) of less than 8% within the same day and 15% 
      between days (results were obtained after normalization by the sum of peak areas, 
      each one being acquired by selected ion monitoring (SIM)). Possible application 
      toward batch comparison of samples is discussed. Chromatographic profiles are 
      compared using the cosine function for evaluating similarity and/or dissimilarity 
      among exhibits.
FAU - Gimeno, Pascal
AU  - Gimeno P
AD  - Laboratoire de Police Scientifique de Lyon, 31 Avenue Franklin Roosevelt, 69134 
      Ecully, France.
FAU - Besacier, Fabrice
AU  - Besacier F
FAU - Chaudron-Thozet, Huguette
AU  - Chaudron-Thozet H
FAU - Girard, Josiane
AU  - Girard J
FAU - Lamotte, Alain
AU  - Lamotte A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - *Drug Contamination
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hallucinogens/*analysis/chemistry
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/chemistry
MH  - Reproducibility of Results
RF  - 37
EDAT- 2002/07/06 10:00
MHDA- 2002/08/28 10:01
CRDT- 2002/07/06 10:00
PHST- 2002/07/06 10:00 [pubmed]
PHST- 2002/08/28 10:01 [medline]
PHST- 2002/07/06 10:00 [entrez]
AID - S0379073802001226 [pii]
AID - 10.1016/s0379-0738(02)00122-6 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2002 Jun 25;127(1-2):1-44. doi: 10.1016/s0379-0738(02)00122-6.