PMID- 12099619
OWN - NLM
STAT- MEDLINE
DCOM- 20030207
LR  - 20220408
IS  - 0960-3271 (Print)
IS  - 0960-3271 (Linking)
VI  - 21
IP  - 4
DP  - 2002 Apr
TI  - Induction of oxidative stress and acetylcholinesterase inhibition in 
      organophosphorous pesticide manufacturing workers.
PG  - 179-82
AB  - Oxidative stress status and acetylcholinesterase (AChE) activity were studied in 
      blood samples obtained from 45 organophosphorous (OP)-formulating pesticide 
      workers with a minimum work history of 1 year in the age range of 23-55. Controls 
      were age-matched workers of a food-making factory. They were evaluated for 
      oxidative stress markers, including thiobarbituric acid-reactive substances 
      (TBARS) indicator of lipid peroxidation (LPO), ferric-reducing ability of plasma 
      (FRAP) indicator of total anti-oxidant capacity, total thiol (SH) groups and 
      gamma glutamyl transpeptidase (GGT) levels in blood and AChE activity in 
      erythrocytes. The results show marked inhibition of AChE activity, increased 
      TBARS, decreased FRAP and decreased thiol group levels in workers. The reduction 
      in activity of AChE correlated well with increased TBARS and decreased FRAP in OP 
      formulators. It is concluded that OP-formulating workers are exposed to more 
      oxidative stress. The measurement of erythrocyte AChE activity in pesticide 
      workers who formulate OPs can be a good monitoring factor and is recommended to 
      be performed in a regular manner.
FAU - Ranjbar, A
AU  - Ranjbar A
AD  - Department of Biochemistry, Faculty of Medicine, Tehran University of Medical 
      Sciences, Iran.
FAU - Pasalar, P
AU  - Pasalar P
FAU - Abdollahi, M
AU  - Abdollahi M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Pesticides)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/blood/*drug effects
MH  - Adult
MH  - Cohort Studies
MH  - Humans
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/*adverse effects
MH  - Organophosphorus Compounds/*adverse effects
MH  - Oxidative Stress/*drug effects
MH  - Pesticides/*adverse effects
MH  - Retrospective Studies
MH  - Sulfhydryl Compounds/blood
MH  - Thiobarbituric Acid Reactive Substances/analysis
MH  - gamma-Glutamyltransferase/blood
EDAT- 2002/07/09 10:00
MHDA- 2003/02/08 04:00
CRDT- 2002/07/09 10:00
PHST- 2002/07/09 10:00 [pubmed]
PHST- 2003/02/08 04:00 [medline]
PHST- 2002/07/09 10:00 [entrez]
AID - 10.1191/0960327102ht238oa [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2002 Apr;21(4):179-82. doi: 10.1191/0960327102ht238oa.