PMID- 12100081
OWN - NLM
STAT- MEDLINE
DCOM- 20020910
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 57
IP  - 1
DP  - 2002 Jul
TI  - Ectopic growth hormone-releasing hormone secretion by thymic carcinoid tumour.
PG  - 131-4
AB  - The case of a 33-year-old-woman with Multiple Endocrine Neoplasia Type 1 (MEN1) 
      syndrome and acromegaly due to ectopic growth hormone-releasing hormone (GHRH) 
      secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed 
      positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, 
      somatostatin and alpha-subunit in the tumour cells. A previously undescribed new 
      germ line mutation of the MEN1 protein gene was revealed.
FAU - Boix, E
AU  - Boix E
AD  - Department of Endocrinology, Universitary Hospital of Alicante, University Miguel 
      Hernandez, Spain. ev.boixc@coma.es
FAU - Pico, A
AU  - Pico A
FAU - Pinedo, R
AU  - Pinedo R
FAU - Aranda, I
AU  - Aranda I
FAU - Kovacs, K
AU  - Kovacs K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Peptides, Cyclic)
RN  - 0G3DE8943Y (lanreotide)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 51110-01-1 (Somatostatin)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
SB  - IM
MH  - Acromegaly/drug therapy/*etiology
MH  - Adult
MH  - Antineoplastic Agents/therapeutic use
MH  - Carcinoid Tumor/chemistry/drug therapy/*metabolism
MH  - Fatal Outcome
MH  - Female
MH  - Germ-Line Mutation
MH  - Growth Hormone-Releasing Hormone/analogs & derivatives/analysis/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Multiple Endocrine Neoplasia Type 1/chemistry/drug therapy/genetics/*metabolism
MH  - Neoplasm Proteins/analysis/*metabolism
MH  - Peptides, Cyclic/therapeutic use
MH  - Somatostatin/analogs & derivatives/analysis/therapeutic use
MH  - Thymus Neoplasms/chemistry/*metabolism
MH  - Vasoactive Intestinal Peptide/analysis
EDAT- 2002/07/09 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/07/09 10:00
PHST- 2002/07/09 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/07/09 10:00 [entrez]
AID - 1535 [pii]
AID - 10.1046/j.1365-2265.2002.01535.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2002 Jul;57(1):131-4. doi: 
      10.1046/j.1365-2265.2002.01535.x.