PMID- 12100384
OWN - NLM
STAT- MEDLINE
DCOM- 20030808
LR  - 20190819
IS  - 0042-9007 (Print)
IS  - 0042-9007 (Linking)
VI  - 83
IP  - 1
DP  - 2002 Jul
TI  - A direct comparison of the antigen-specific antibody profiles of intravenous 
      immunoglobulins derived from US and UK donor plasma.
PG  - 17-22
AB  - BACKGROUND AND OBJECTIVES: Intravenous immunoglobulin (IVIG) is used in a range 
      of immunodeficiency states that require a broad spectrum of protective antibodies 
      to a range of common pathogens. A comparison of the antigen-specific antibody 
      profile of preparations of an IVIG (Vigam) derived from US and UK sourced plasma 
      was performed, and these preparations were also compared with three other IVIG 
      products from different manufacturers. MATERIALS AND METHODS: Antibodies against 
      a range of bacterial and viral pathogens were measured by immunoassay. RESULTS: 
      Similar profiles were found for Vigam made from UK and US source plasma and also 
      for the other three IVIGs tested, but some specific differences were observed. 
      CONCLUSIONS: IVIG preparations have a similar therapeutic spectrum of antibodies 
      when prepared from plasma sourced either from the UK or the US.
FAU - Matejtschuk, P
AU  - Matejtschuk P
AD  - Bio Products Laboratory, Elstree, Herts., UK.
FAU - Chidwick, K
AU  - Chidwick K
FAU - Prince, A
AU  - Prince A
FAU - More, J E
AU  - More JE
FAU - Goldblatt, D
AU  - Goldblatt D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin Isotypes)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Antibodies, Bacterial/analysis/immunology
MH  - Antibodies, Viral/analysis/immunology
MH  - *Antibody Specificity
MH  - Humans
MH  - Immunoglobulin Isotypes/analysis
MH  - Immunoglobulins, Intravenous/*analysis/immunology
MH  - Titrimetry
MH  - United Kingdom
MH  - United States
EDAT- 2002/07/09 10:00
MHDA- 2003/08/09 05:00
CRDT- 2002/07/09 10:00
PHST- 2002/07/09 10:00 [pubmed]
PHST- 2003/08/09 05:00 [medline]
PHST- 2002/07/09 10:00 [entrez]
AID - 186 [pii]
AID - 10.1046/j.1423-0410.2002.00186.x [doi]
PST - ppublish
SO  - Vox Sang. 2002 Jul;83(1):17-22. doi: 10.1046/j.1423-0410.2002.00186.x.