PMID- 12100686
OWN - NLM
STAT- MEDLINE
DCOM- 20020920
LR  - 20190722
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 41
IP  - 6
DP  - 2002 Jun
TI  - Haplotype associations of the major histocompatibility complex with psoriasis in 
      Northeastern Thais.
PG  - 330-4
AB  - BACKGROUND: To evaluate the distributions of the human leukocyte antigen (HLA) at 
      class I and II loci that may contribute to the genetic susceptibility to 
      psoriasis patients in the north-eastern Thai population. MATERIALS AND METHODS: 
      We analyzed the allelic frequencies of HLA class I and II by using the polymerase 
      chain reaction-amplification refractory mutation system (PCR-ARMS) technique and 
      polymerase chain reaction-single stranded conformation polymorphism (PCR-SSCP), 
      respectively, in 140 north-eastern Thais with psoriasis that were sudivided into 
      two groups: one with age at onset < 40 years (type I psoriasis; 95 cases) and the 
      other with age at onset > 40 years (type II psoriasis; 45 cases). Three hundred 
      healthy unrelated north-eastern Thais were used as controls. RESULTS: HLA-A*01, 
      -A*0207, -A*30, -B*08, -B*13, -B*4601, -B*57, -Cw*01, -Cw*0602, and -DRB1*07 were 
      positively associated with type I psoriasis, whereas HLA-A*24, -A*33, and -Cw*04 
      were negatively associated with type I psoriasis with statistical significance 
      when compared to the controls. The Cw*0602 allele showed the strongest 
      correlation with this type. In addition, the frequencies of HLA-A*0207, -A*30, 
      -Cw*01, and -DRB1*1401 were significantly increased in type II psoriasis. 
      HLA-A*207, -B*4601, -Cw*01, -DRB1*09, -DQB1*0303 (AH46.1), 
      HLA-A*01-B*57-Cw*0602-DRB1*07-DQB1*0303 (AH57.1), and HLA-A*30, -B*13, -Cw*0602, 
      -DRB1*07, and -DQB1*02 (AH13.1) were identified as high-risk major 
      histocompatibility complex (MHC) halotypes for psoriasis patients in the early 
      onset group in north-eastern Thais. CONCLUSIONS: This study demonstrates not only 
      the differential association between HLA markers and types of psoriasis according 
      to age at onset, but also a newly found high-risk and a protective haplotype in 
      Thai psoriasis patients.
FAU - Choonhakarn, Charoen
AU  - Choonhakarn C
AD  - Division of Dermatology, Department of Medicine, Faculty of Medicine, and Blood 
      Transfusion Center, Khon Kaen University, Khon Kaen 40002, Thailand. 
      c_choonhakarn_dematologist@hotmail.com
FAU - Romphruk, Amornrat
AU  - Romphruk A
FAU - Puapairoj, Chintana
AU  - Puapairoj C
FAU - Jirarattanapochai, Kunya
AU  - Jirarattanapochai K
FAU - Romphruk, Arunrat
AU  - Romphruk A
FAU - Leelayuwat, Chanvit
AU  - Leelayuwat C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Locus Control Region/genetics
MH  - Odds Ratio
MH  - Psoriasis/*genetics
MH  - Thailand
EDAT- 2002/07/09 10:00
MHDA- 2002/09/21 10:01
CRDT- 2002/07/09 10:00
PHST- 2002/07/09 10:00 [pubmed]
PHST- 2002/09/21 10:01 [medline]
PHST- 2002/07/09 10:00 [entrez]
AID - 1496 [pii]
AID - 10.1046/j.1365-4362.2002.01496.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2002 Jun;41(6):330-4. doi: 10.1046/j.1365-4362.2002.01496.x.