PMID- 12103264
OWN - NLM
STAT- MEDLINE
DCOM- 20020726
LR  - 20220330
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 40
IP  - 1
DP  - 2002 Jul 3
TI  - Long-term benefits of biventricular pacing in congestive heart failure: results 
      from the MUltisite STimulation in cardiomyopathy (MUSTIC) study.
PG  - 111-8
AB  - OBJECTIVES: The main objective of this study was to assess if the benefits of 
      biventricular (BiV) pacing observed during the crossover phase were sustained 
      over 12 months. BACKGROUND: MUltisite STimulation In Cardiomyopathies (MUSTIC) is 
      a randomized controlled study intended to evaluate the effects of BiV pacing in 
      patients with New York Heart Association (NYHA) class III heart failure and 
      intraventricular conduction delay. METHODS: Of 131 patients included, 42/67 in 
      sinus rhythm (SR) and 33/64 in atrial fibrillation (AF) were followed up 
      longitudinally at 9 and 12 months by 6-min walked distance, peak oxygen uptake 
      (peak VO(2)), quality of life by the Minnesota score, NYHA class, 
      echocardiography, and left ventricular ejection fraction by radionuclide 
      technique. RESULTS: At 12 months, all SR and 88% of AF patients were programmed 
      to BiV pacing. Compared with baseline, the 6-min walked distance increased by 20% 
      (SR) (p = 0.0001) and 17% (AF) (p = 0.004); the peak VO(2) by 11% (SR) and 9% 
      (AF); quality of life improved by 36% (SR) (p = 0.0001) and 32% (AF) (p = 0.002); 
      NYHA class improved by 25% (SR) (p = 0.0001) and 27% (AF) (p = 0.0001). The 
      ejection fraction improved by 5% (SR) and 4% (AF). Mitral regurgitation decreased 
      by 45% (SR) and 50% (AF). CONCLUSIONS: The clinical benefits of BiV pacing 
      appeared to be significantly maintained over a 12-month follow-up period.
FAU - Linde, Cecilia
AU  - Linde C
AD  - Department of Cardiology, Karolinska Hospital, Stockholm, Sweden. 
      cecilia.linde@ks.se
FAU - Leclercq, Christophe
AU  - Leclercq C
FAU - Rex, Steve
AU  - Rex S
FAU - Garrigue, Stephane
AU  - Garrigue S
FAU - Lavergne, Thomas
AU  - Lavergne T
FAU - Cazeau, Serge
AU  - Cazeau S
FAU - McKenna, William
AU  - McKenna W
FAU - Fitzgerald, Melissa
AU  - Fitzgerald M
FAU - Deharo, Jean-Claude
AU  - Deharo JC
FAU - Alonso, Christine
AU  - Alonso C
FAU - Walker, Stuart
AU  - Walker S
FAU - Braunschweig, Frieder
AU  - Braunschweig F
FAU - Bailleul, Christophe
AU  - Bailleul C
FAU - Daubert, Jean-Claude
AU  - Daubert JC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
CIN - J Am Coll Cardiol. 2003 Feb 19;41(4):709; author reply 709-10. PMID: 12598087
MH  - Aged
MH  - Atrial Fibrillation/therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Case-Control Studies
MH  - Cross-Over Studies
MH  - Electrocardiography
MH  - Exercise Tolerance
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*therapy
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial
MH  - Quality of Life
MH  - Single-Blind Method
MH  - Time Factors
EDAT- 2002/07/10 10:00
MHDA- 2002/07/27 10:01
CRDT- 2002/07/10 10:00
PHST- 2002/07/10 10:00 [pubmed]
PHST- 2002/07/27 10:01 [medline]
PHST- 2002/07/10 10:00 [entrez]
AID - S0735109702019320 [pii]
AID - 10.1016/s0735-1097(02)01932-0 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2002 Jul 3;40(1):111-8. doi: 10.1016/s0735-1097(02)01932-0.