PMID- 12103376
OWN - NLM
STAT- MEDLINE
DCOM- 20020926
LR  - 20190513
IS  - 1010-7940 (Print)
IS  - 1010-7940 (Linking)
VI  - 22
IP  - 1
DP  - 2002 Jul
TI  - Report of the Dutch experience with the Ross procedure in 343 patients.
PG  - 70-7
AB  - OBJECTIVE: Limited information is available on outcome after autograft aortic 
      valve replacement, in particular with respect to the durability of the autograft 
      and of the allograft used to reconstruct the right ventricular outflow tract. A 
      retrospective follow-up study of all patients who underwent a Ross procedure in 
      the Netherlands since 1988 was done to obtain an overview of the Dutch experience 
      with this procedure. METHODS: From 1988 to January 2000, 348 Ross procedures were 
      performed in nine centers in the Netherlands. Pre-operative, peri-operative and 
      follow-up data from 343 patients in seven centers (99% of all Dutch autograft 
      patients) were collected and analyzed. RESULTS: Mean patient age was 26 years (SD 
      14, range 0-58) and male/female ratio was 2.1. Bicuspid valve or other congenital 
      heart valve disease was the most common indication for operation. The root 
      replacement technique was used in 95% of patients and concomitant procedures were 
      done in 12%. Hospital mortality was 2.6% (N=9). Mean follow-up was 4 years 
      (median 3.8, SD 2.8, range 0-12.5). Overall cumulative survival was 96% at 1 year 
      (95% confidence interval (CI) 94-98%) and 94% at 5 and 7 post-operative years, 
      respectively (95% CI 91-97%). At last follow-up, 87% of the surviving patients 
      was in New York Heart Association (NYHA) class I. Independent predictors of 
      overall mortality were pre-operative NYHA class IV/V and longer perfusion time. 
      Autograft reoperation had to be performed in 14 patients and reintervention on 
      the pulmonary allograft in 10 patients. Freedom from any valve-related 
      reintervention was 88% at 7 years (95% CI 81-94%). CONCLUSIONS: The Dutch 
      experience with the Ross procedure is favorable, with low operative mortality and 
      good mid-term results. Although both the autograft in aortic position and the 
      allograft in the right ventricular outflow tract have a limited durability, this 
      has not yet resulted in considerable reoperation rates and associated morbidity 
      and mortality.
FAU - Takkenberg, J J M
AU  - Takkenberg JJ
AD  - Department of Cardio-Thoracic Surgery, Erasmus Medical Center, Rotterdam, The 
      Netherlands. takkenberg@thch.azr.nl
FAU - Dossche, K M E
AU  - Dossche KM
FAU - Hazekamp, M G
AU  - Hazekamp MG
FAU - Nijveld, A
AU  - Nijveld A
FAU - Jansen, E W L
AU  - Jansen EW
FAU - Waterbolk, T W
AU  - Waterbolk TW
FAU - Bogers, A J J C
AU  - Bogers AJ
CN  - Dutch Ross Study Group
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aortic Valve/*surgery/transplantation
MH  - Cardiac Surgical Procedures/mortality
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Heart Valve Diseases/*surgery
MH  - Heart Ventricles/surgery
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Pulmonary Valve/surgery
MH  - Retrospective Studies
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
MH  - Treatment Outcome
EDAT- 2002/07/10 10:00
MHDA- 2002/09/27 06:00
CRDT- 2002/07/10 10:00
PHST- 2002/07/10 10:00 [pubmed]
PHST- 2002/09/27 06:00 [medline]
PHST- 2002/07/10 10:00 [entrez]
AID - S1010794002002026 [pii]
AID - 10.1016/s1010-7940(02)00202-6 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2002 Jul;22(1):70-7. doi: 10.1016/s1010-7940(02)00202-6.