PMID- 12105114
OWN - NLM
STAT- MEDLINE
DCOM- 20020802
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 965
DP  - 2002 Jun
TI  - Striatal postsynaptic ultrastructural alterations following 
      methylenedioxymethamphetamine administration.
PG  - 381-98
AB  - Amphetamine derivatives, such as methamphetamine (METH) and 
      3,4-methylenedioxymethamphetamine (MDMA), act as monoaminergic neurotoxins in the 
      central nervous system. Although there are slight differences in their mechanism 
      of action, these compounds share a final common pathway, which involves dopamine 
      release and oxidative stress. Apart from striatal toxicity involving monoamine 
      axons, no previous report evidenced any alteration at the striatal level 
      concerning postsynaptic sites. Given the potential toxicity for extracellular 
      dopamine at the striatal level, and the hypothesis for neurotoxic effects of 
      dopamine on striatal medium-sized neurons in Huntington's disease, we evaluated 
      at an ultrastructural level the effects of MDMA on intrinsic striatal neurons of 
      the mouse. In this study, administering MDMA, we noted ultrastructural 
      alterations of striatal postsynaptic GABAergic cells consisting of neuronal 
      inclusions shaped as whorls of concentric membranes. These whorls stained for 
      ubiquitin but not for synuclein and represent the first morphologic correlate of 
      striatal postsynaptic effects induced by MDMA.
FAU - Fornai, F
AU  - Fornai F
AD  - Department of Human Morphology and Applied Biology, University of Pisa, Pisa, 
      Italy. f.fornai@med.unipi.it
FAU - Gesi, M
AU  - Gesi M
FAU - Lenzi, P
AU  - Lenzi P
FAU - Ferrucci, M
AU  - Ferrucci M
FAU - Pellegrini, A
AU  - Pellegrini A
FAU - Ruggieri, S
AU  - Ruggieri S
FAU - Casini, A
AU  - Casini A
FAU - Paparelli, A
AU  - Paparelli A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Benzylamines)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Phosphatidylcholines)
RN  - EDS2L3ODLV (1,2-oleoylphosphatidylcholine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - PQ1P7JP5C1 (DSP 4)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Benzylamines/administration & dosage/toxicity
MH  - Biogenic Monoamines/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Corpus Striatum/drug effects/metabolism/*ultrastructure
MH  - Dopamine/metabolism
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Phosphatidylcholines/metabolism
MH  - Synapses/drug effects/*ultrastructure
EDAT- 2002/07/10 10:00
MHDA- 2002/08/03 10:01
CRDT- 2002/07/10 10:00
PHST- 2002/07/10 10:00 [pubmed]
PHST- 2002/08/03 10:01 [medline]
PHST- 2002/07/10 10:00 [entrez]
AID - 10.1111/j.1749-6632.2002.tb04180.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2002 Jun;965:381-98. doi: 10.1111/j.1749-6632.2002.tb04180.x.