PMID- 12105277
OWN - NLM
STAT- MEDLINE
DCOM- 20030107
LR  - 20151119
IS  - 1071-7323 (Print)
IS  - 1071-7323 (Linking)
VI  - 10
IP  - 7
DP  - 2002 Jul
TI  - Effects of obesity on substrate utilization during exercise.
PG  - 575-84
AB  - OBJECTIVE: The capacity for lipid and carbohydrate (CHO) oxidation during 
      exercise is important for energy partitioning and storage. This study examined 
      the effects of obesity on lipid and CHO oxidation during exercise. RESEARCH 
      METHODS AND PROCEDURES: Seven obese and seven lean [body mass index (BMI), 33 +/- 
      0.8 and 23.7 +/- 1.2 kg/m(2), respectively] sedentary, middle-aged men matched 
      for aerobic capacity performed 60 minutes of cycle exercise at similar relative 
      (50% VO(2max)) and absolute exercise intensities. RESULTS: Obese men derived a 
      greater proportion of their energy from fatty-acid oxidation than lean men (43 
      +/- 5% 31 +/- 2%; p = 0.02). Plasma fatty-acid oxidation determined from recovery 
      of infused [0.15 micromol/kg fat-free mass (FFM) per minute] [1-(13)C]-palmitate 
      in breath CO(2) was similar for obese and lean men (8.4 +/- 1.1 and 29 +/- 15 
      micromol/kg FFM per minute). Nonplasma fatty-acid oxidation, presumably, from 
      intramuscular sources, was 50% higher in obese men than in lean men (10.0 +/- 0.6 
      versus 6.6 +/- 0.8 micromol/kg FFM per minute; p < 0.05). Systemic glucose 
      disposal was similar in lean and obese groups (33 +/- 8 and 29 +/- 15 micromol/kg 
      FFM per minute). However, the estimated rate of glycogen-oxidation was 50% lower 
      in obese than in lean men (61 +/- 12 versus 90 +/- 6 micromol/kg FFM per minute; 
      p < 0.05). DISCUSSION: During moderate exercise, obese sedentary men have 
      increased rates of fatty-acid oxidation from nonplasma sources and reduced rates 
      of CHO oxidation, particularly muscle glycogen, compared with lean sedentary men.
FAU - Goodpaster, Bret H
AU  - Goodpaster BH
AD  - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, 
      USA.
FAU - Wolfe, Robert R
AU  - Wolfe RR
FAU - Kelley, David E
AU  - Kelley DE
LA  - eng
GR  - 1P30DK46204/DK/NIDDK NIH HHS/United States
GR  - 5M01RR0056/RR/NCRR NIH HHS/United States
GR  - K01 AG00851/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Obes Res
JT  - Obesity research
JID - 9305691
RN  - 0 (Blood Glucose)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 2V16EO95H1 (Palmitic Acid)
RN  - 9005-79-2 (Glycogen)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Breath Tests
MH  - Carbon Isotopes
MH  - Energy Metabolism
MH  - *Exercise
MH  - Fatty Acids/blood/metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Glycogen/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Kinetics
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - Norepinephrine/blood
MH  - Obesity/*metabolism
MH  - Oxidation-Reduction
MH  - Oxygen Consumption
MH  - Palmitic Acid/blood
EDAT- 2002/07/10 10:00
MHDA- 2003/01/08 04:00
CRDT- 2002/07/10 10:00
PHST- 2002/07/10 10:00 [pubmed]
PHST- 2003/01/08 04:00 [medline]
PHST- 2002/07/10 10:00 [entrez]
AID - 10.1038/oby.2002.78 [doi]
PST - ppublish
SO  - Obes Res. 2002 Jul;10(7):575-84. doi: 10.1038/oby.2002.78.