PMID- 12105780
OWN - NLM
STAT- MEDLINE
DCOM- 20030711
LR  - 20071115
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 30
IP  - 1
DP  - 2002 Jul
TI  - Isolated extramedullary relapse in the pleural fluid of a patient with acute 
      myeloid leukemia following allogeneic BMT.
PG  - 57-9
AB  - We report an unusual case of AML, in which the patient showed extramedullary 
      relapse in the pleural fluid and the skin without bone marrow recurrence even 3 
      years after allogeneic BMT. On examination of the pleural effusion and the skin, 
      which relapsed 31 months and 40 months, respectively, after BMT, we found that 
      most of cells were as the XY-type recipient by quantitative X/Y FISH 
      (fluorescence in situ hybridization). However, 100% of the bone marrow cells 
      remained XX-type donor cells. In the present case, we believe that the 
      graft-versus-leukemia (GVL) response in the extramedullary site was not so 
      effective as that in the bone marrow, where it remains effective.
FAU - Park, J
AU  - Park J
AD  - Department of Clinical Pathology, College of Medicine, Seoul National University, 
      Seoul, Korea.
FAU - Park, S Y
AU  - Park SY
FAU - Cho, H I
AU  - Cho HI
FAU - Lee, D
AU  - Lee D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Graft vs Leukemia Effect
MH  - Humans
MH  - Leukemia/etiology
MH  - Leukemia, Myeloid/*pathology/therapy
MH  - Male
MH  - Pleural Effusion, Malignant/*etiology
MH  - Recurrence
MH  - Sarcoma, Myeloid/*etiology
MH  - Transplantation, Homologous
EDAT- 2002/07/10 10:00
MHDA- 2003/07/12 05:00
CRDT- 2002/07/10 10:00
PHST- 2001/11/20 00:00 [received]
PHST- 2002/04/04 00:00 [accepted]
PHST- 2002/07/10 10:00 [pubmed]
PHST- 2003/07/12 05:00 [medline]
PHST- 2002/07/10 10:00 [entrez]
AID - 10.1038/sj.bmt.1703572 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2002 Jul;30(1):57-9. doi: 10.1038/sj.bmt.1703572.