PMID- 12106170
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 1
IP  - 1
DP  - 1989 Jan
TI  - Survival and Axonal Elongation of Adult Rat Retinal Ganglion Cells.
PG  - 19-26
AB  - A peripheral nerve exudate, collected in situ from the proximal end of a severed 
      rat sciatic nerve, can induce substantial axonal elongation from ganglion cells 
      when tested on explanted adult rat retinae. The responsive cells are identified 
      on the basis of their Thy 1.1 immunostaining properties. Similar outgrowth can be 
      obtained from explants when the culture medium is supplemented with brain-derived 
      neurotrophic factor (BDNF). In addition, both BDNF and the sciatic nerve exudate 
      can prevent ganglion cell degeneration as shown by the retrograde transport of a 
      fluorescent dye that had been applied to the superior colliculus prior to 
      explantation. The results demonstrate that soluble components, released by 
      lesioned peripheral nerves, can effect adult retinal ganglion cells in a way that 
      is reminiscent of that which has been described in vivo using sciatic nerve 
      grafts after sectioning of the optic nerve. The molecular nature of these 
      components is discussed.
FAU - Thanos, Solon
AU  - Thanos S
AD  - Max-Planck-Institut fur Entwicklungsbiologie, Spemannstr. 35/I, D-7400 Tubingen, 
      FRG.
FAU - Bahr, Mathias
AU  - Bahr M
FAU - Barde, Yves-Alain
AU  - Barde YA
FAU - Vanselow, Jens
AU  - Vanselow J
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
EDAT- 1989/01/01 00:00
MHDA- 2002/07/11 10:00
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 2002/07/11 10:00 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - ejn_01010019 [pii]
AID - 10.1111/j.1460-9568.1989.tb00770.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1989 Jan;1(1):19-26. doi: 10.1111/j.1460-9568.1989.tb00770.x.