PMID- 12106253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 3
IP  - 10
DP  - 1991
TI  - Developmentally Regulated Expression of HDNF/NT-3 mRNA in Rat Spinal Cord 
      Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion.
PG  - 953-961
AB  - Northern blot analysis was used to demonstrate high levels of hippocampus-derived 
      neurotrophic factor/neurotrophin-3 (HDNF/NT-3) mRNA in the embryonic day (E) 13 - 
      14 and 15 - 16 spinal cord. The level decreased at E18 - 19 and remained the same 
      until postnatal day (P) 1, after which it decreased further to a level below the 
      detection limit in the adult. In situ hybridization revealed that the NT-3 mRNA 
      detected in the developing spinal cord was derived from motoneurons and the 
      decrease seen at E18 - 19 was caused by a reduction in the number of motoneurons 
      expressing NT-3 mRNA. The distribution of NT-3 mRNA-expressing cells in the E15 
      spinal cord was very similar to the distribution of cells expressing choline 
      acetyltransferase or nerve growth factor receptor (NGFR) mRNA. Moreover, a 
      striking similarity between the developmentally regulated expression of NT-3 and 
      NGFR mRNA was noted in spinal cord motoneurons. A subpopulation of all neurons in 
      the dorsal root ganglia expressed brain-derived neurotrophic factor (BDNF) mRNA 
      from E13, the earliest time examined, to adulthood. These results are consistent 
      with a trophic role of NT-3 for proprioceptive sensory neurons innervating the 
      ventral horn, and imply a local action of BDNF for developing sensory neurons 
      within the dorsal root ganglia.
FAU - Ernfors, Patrik
AU  - Ernfors P
AD  - Department of Medical Chemistry, Laboratory of Molecular Neurobiology, Karolinska 
      Institute, Box 60400, S-104 01 Stockholm, Sweden.
FAU - Persson, Hakan
AU  - Persson H
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
EDAT- 1991/01/01 00:00
MHDA- 2002/07/11 10:00
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 2002/07/11 10:00 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - ejn_03100953 [pii]
AID - 10.1111/j.1460-9568.1991.tb00031.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1991;3(10):953-961. doi: 10.1111/j.1460-9568.1991.tb00031.x.