PMID- 12106347
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 4
IP  - 5
DP  - 1992
TI  - Regulation of Neurotrophin mRNA Expression in the Rat Brain by Glucocorticoids.
PG  - 396-403
AB  - Northern blot analysis was used to examine the effects of glucocorticoids on 
      neurotrophin mRNA expression in the rat cerebral cortex and hippocampus. The 
      results show that 3 days after adrenalectomy the mRNA levels for nerve growth 
      factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) 
      decreased significantly in both these regions. In adrenalectomized animals given 
      dexamethasone replacement the mRNA levels for the three neurotrophins were 
      restored to control levels. The effect of a single dose of dexamethasone (5 
      mg/kg) administered i.p. to intact animals on the expression of neurotrophins was 
      also examined. NGF and NT-3 mRNAs showed a 2.5-fold and a 1.4-fold increase, 
      respectively, during the first 4 h after the injection. The increase was followed 
      by a decrease, with levels approximately 50% of control 24 and 48 h after the 
      injection. In contrast, the level of BDNF mRNA did not change during the first 10 
      h after the injection, but decreased to 70% of control 48 h after the injection. 
      These data indicate that glucocorticoids regulate neurotrophin mRNA expression 
      both in the cortex and in the hippocampus, and suggest further that the known 
      effects of glucocorticoids on neuronal survival in the brain could be due to 
      changes in the levels of neurotrophins in the brain.
FAU - Barbany, Gisela
AU  - Barbany G
AD  - Department of Medical Chemistry, Laboratory of Molecular Neurobiology, Karolinska 
      Institute, Box 60400, S-10401 Stockholm, Sweden.
FAU - Persson, Hakan
AU  - Persson H
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
EDAT- 1992/01/01 00:00
MHDA- 2002/07/11 10:00
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 2002/07/11 10:00 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - ejn_04050396 [pii]
AID - 10.1111/j.1460-9568.1992.tb00888.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1992;4(5):396-403. doi: 10.1111/j.1460-9568.1992.tb00888.x.