PMID- 12106476
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 3
IP  - 7
DP  - 1991 Jul
TI  - Cells that Express Brain-Derived Neurotrophic Factor mRNA in the Developing 
      Postnatal Rat Brain.
PG  - 688-697
AB  - Brain-derived neurotrophic factor (BDNF) is a member of a family of related 
      neurotrophic proteins which includes nerve growth factor (NGF) and 
      hippocampus-derived neurotrophic factor/neurotrophin-3 (NT-3). To obtain 
      information regarding possible roles for BDNF during postnatal brain development, 
      we have examined the temporal and spatial expression of this trophic factor using 
      in situ hybridization. In specific neocortical regions BDNF mRNA-expressing cells 
      were seen at 2 weeks of age and thereafter. One particular neuronal cell type 
      strikingly labelled was the inverted pyramidal cell population in the deep layers 
      of parietotemporal cortex. In pyriform and cingulate cortices, BDNF mRNA was 
      detected at postnatal day 1 and 1 week of age, respectively, with increasing 
      levels during ontogeny. Several forebrain regions, including the thalamic 
      anterior paraventricular nucleus, hypothalamic ventromedial nucleus as well as 
      the preoptic area, contained moderate levels of BDNF mRNA throughout development. 
      BDNF mRNA was detected transiently in several brainstem structures, notably in 
      the substantia nigra and interpeduncular nucleus. Expression of this trophic 
      factor in hippocampus was relatively low in the early neonatal brain, but 
      attained high levels in the CA3 and CA4 regions as well as in the dentate gyrus 
      by 2 weeks of age. At this early age, which is still during the period of 
      neurogenesis in the dentate gyrus, labelling was restricted to the outer layer, 
      which contained cells with a more mature appearance. However, by 3 weeks of age 
      labelling was distributed throughout the granule cell layer. Our results show 
      both transient and persistent expression of BDNF mRNA in various regions of the 
      developing rat brain and suggest that there is a caudal to rostral gradient of 
      BDNF expression during postnatal brain development, which may be correlated to 
      neuronal maturation.
FAU - Friedman, Wilma J
AU  - Friedman WJ
AD  - Departments of Medical Chemistry, Laboratory of Molecular Neurobiology and.
FAU - Olson, Lars
AU  - Olson L
FAU - Persson, Hakan
AU  - Persson H
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
EDAT- 1991/07/01 00:00
MHDA- 2002/07/11 10:00
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 2002/07/11 10:00 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - ejn_03070688 [pii]
AID - 10.1111/j.1460-9568.1991.tb00854.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1991 Jul;3(7):688-697. doi: 10.1111/j.1460-9568.1991.tb00854.x.