PMID- 12107090
OWN - NLM
STAT- MEDLINE
DCOM- 20020806
LR  - 20190108
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 161
IP  - 1
DP  - 2002 Jul
TI  - Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and 
      mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along 
      different pathogenetic pathways.
PG  - 63-71
AB  - t(11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in 
      mucosa-associated lymphoid tissue (MALT) lymphomas. To investigate their 
      relationship and clinical significance, we developed a two-color fluorescence in 
      situ hybridization (FISH) technique to detect t(11;18) and aneuploidy in nuclei 
      isolated from paraffin-embedded tissue. Thirty-seven MALT lymphomas (all 
      previously evaluated for t(11;18) by reverse transcriptase-polymerase chain 
      reaction), 1 large cell lymphoma (LCL) arising subsequent to MALT lymphoma, and 
      16 controls were tested by FISH using the t(11;18) probe set and multiple 
      centromeric probes. t(11;18)(q21;q21) was present by FISH in 11 of 12 polymerase 
      chain reaction-positive MALT lymphomas (92%). The LCL and its clonally identical 
      antecedent MALT lymphoma both showed t(11;18). The LCL had trisomy 12, and a 
      small subset of MALT lymphoma cells had trisomy 3 and/or 12. Only one other MALT 
      lymphoma with t(11;18) showed aneuploidy (trisomy 3) in a small clone, whereas 15 
      of 25 t(11;18)-negative MALT lymphomas (60%) showed trisomy of chromosomes 18 (n 
      = 12), 3 (n = 8), 7 (n = 2), and/or 11 (n = 1). t(11;18) and aneuploidy are 
      primarily mutually exclusive events, suggesting different pathogenetic pathways 
      in the development of MALT lymphomas. Both t(11;18) and aneuploidy were seen 
      disproportionately in lung, and both were associated with recurrent disease.
FAU - Remstein, Ellen D
AU  - Remstein ED
AD  - Division of Anatomic Pathology and Hematopathology, Mayo Clinic, Rochester, 
      Minnesota 55905, USA. remstein.ellen@mayo.edu
FAU - Kurtin, Paul J
AU  - Kurtin PJ
FAU - James, C David
AU  - James CD
FAU - Wang, Xiao-Yang
AU  - Wang XY
FAU - Meyer, Reid G
AU  - Meyer RG
FAU - Dewald, Gordon W
AU  - Dewald GW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aneuploidy
MH  - *Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 18
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Lymphoma, Large B-Cell, Diffuse/genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
MH  - Trisomy
PMC - PMC1850705
EDAT- 2002/07/11 10:00
MHDA- 2002/08/07 10:01
PMCR- 2003/01/01
CRDT- 2002/07/11 10:00
PHST- 2002/07/11 10:00 [pubmed]
PHST- 2002/08/07 10:01 [medline]
PHST- 2002/07/11 10:00 [entrez]
PHST- 2003/01/01 00:00 [pmc-release]
AID - S0002-9440(10)64157-0 [pii]
AID - 3209 [pii]
AID - 10.1016/S0002-9440(10)64157-0 [doi]
PST - ppublish
SO  - Am J Pathol. 2002 Jul;161(1):63-71. doi: 10.1016/S0002-9440(10)64157-0.