PMID- 12107223
OWN - NLM
STAT- MEDLINE
DCOM- 20020802
LR  - 20041117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 87
IP  - 7
DP  - 2002 Jul
TI  - Type-2 diabetes family history delays the onset of type-1 diabetes.
PG  - 3192-6
AB  - Type-1 diabetes (T1D) is an autoimmune disease leading to insulin deficiency. Its 
      occurrence is influenced by genetic and environmental factors. The human 
      leukocyte antigen (HLA) region on chromosome 6 accounts for 45% of the genetic 
      susceptibility for the disease, mainly the HLA-DQB1*0201 and HLA-DQB1*0302 
      alleles. Among the environmental factors involved, early exposure to cow's milk 
      seems to be a trigger. In this study, we investigated the occurrence of T1D in 
      253 Lebanese Caucasian patients, in relation to HLA-DQB1*0201, HLA-DQB1*0302, 
      HLA-DQB1*0602, gender, and early exposure to cow's milk, as well as to family 
      history of T1D and type-2 diabetes (T2D). Our genetic analysis results show that 
      in the patients studied, 77% and 40% were positive for BQ1*0201 and BQ1*0302, 
      respectively. As for BQ1*0602, only 0.8% of patients were positive for this T1D 
      protective allele, compared with 24% among the controls. Furthermore, our results 
      did not show any gender preference of the disease or any effects of early intake 
      of cow's milk on the age at onset of T1D. When family history of T2D or T1D was 
      studied, our results show a novel finding whereby an immediate family history of 
      T2D, but not T1D, delays the age at onset of T1D.
FAU - Zalloua, P A
AU  - Zalloua PA
AD  - Program for Population Genetics, Harvard School of Public Health, Boston, MA 
      02115, USA.
FAU - Shbaklo, H
AU  - Shbaklo H
FAU - Halaby, G
AU  - Halaby G
FAU - Terwedow, H
AU  - Terwedow H
FAU - Xu, X
AU  - Xu X
FAU - Azar, S T
AU  - Azar ST
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Animals
MH  - Diabetes Mellitus, Type 1/*epidemiology
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Drinking
MH  - Female
MH  - Genotype
MH  - HLA Antigens/analysis
MH  - Humans
MH  - Male
MH  - *Medical Records
MH  - Milk
EDAT- 2002/07/11 10:00
MHDA- 2002/08/03 10:01
CRDT- 2002/07/11 10:00
PHST- 2002/07/11 10:00 [pubmed]
PHST- 2002/08/03 10:01 [medline]
PHST- 2002/07/11 10:00 [entrez]
AID - 10.1210/jcem.87.7.8649 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2002 Jul;87(7):3192-6. doi: 10.1210/jcem.87.7.8649.