PMID- 12108524
OWN - NLM
STAT- MEDLINE
DCOM- 20021224
LR  - 20181113
IS  - 1355-008X (Print)
IS  - 1355-008X (Linking)
VI  - 17
IP  - 3
DP  - 2002 Apr
TI  - A meal stimulation test in the diagnosis of pancreatic endocrine tumors in 
      multiple endocrine neoplasia type 1.
PG  - 229-32
AB  - The diagnostic value of the determination of the serum pancreatic polypeptide 
      (PP) and gastrin concentrations after a standard meal for early diagnosis of 
      patients with multiple endocrine neoplasia type 1 (MEN 1) is controversial. The 
      aim of this study was to clarify this issue. Thirteen patients with MEN 1, seven 
      healthy family members, and eight healthy controls were studied. Plasma PP and 
      serum gastrin were measured before and after the ingestion of a standardized 
      meal. The meal caused a statistically significant (p < 0.05) increase of both PP 
      and gastrin in all three groups studied. Concerning PP, no statistically 
      significant difference was observed between patients and controls. In family 
      members, the values were significantly (p < 0.05) lower than in the other two 
      groups. On the whole, no significant differences in gastrin levels were noted 
      between patients and controls; in family members, the values were significantly 
      (p < 0.05) lower than in patients. All patients who had abnormally high 
      postprandial values of PP and gastrin also had abnormally high basal values of 
      these two peptides. The determination of serum PP and gastrin levels after a meal 
      stimulation test in patients with MEN 1 adds no information about the presence of 
      pancreatic endocrine tumors over that provided by basal values of the two 
      peptides.
FAU - Migliori, M
AU  - Migliori M
AD  - Department of Internal Medicine and Gastroenterology, University of Bologna, S. 
      Orsola Hospital, Italy.
FAU - Tomassetti, P
AU  - Tomassetti P
FAU - Campana, D
AU  - Campana D
FAU - Boschi, S
AU  - Boschi S
FAU - Pezzilli, R
AU  - Pezzilli R
FAU - Piscitelli, L
AU  - Piscitelli L
FAU - Corinaldesi, R
AU  - Corinaldesi R
FAU - Gullo, L
AU  - Gullo L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Gastrins)
RN  - 59763-91-6 (Pancreatic Polypeptide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - *Food
MH  - Gastrins/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis
MH  - Pancreatic Neoplasms/*diagnosis
MH  - Pancreatic Polypeptide/blood
MH  - Postprandial Period/physiology
EDAT- 2002/07/11 10:00
MHDA- 2002/12/27 04:00
CRDT- 2002/07/11 10:00
PHST- 2002/07/11 10:00 [pubmed]
PHST- 2002/12/27 04:00 [medline]
PHST- 2002/07/11 10:00 [entrez]
AID - ENDO:17:3:229 [pii]
AID - 10.1385/ENDO:17:3:229 [doi]
PST - ppublish
SO  - Endocrine. 2002 Apr;17(3):229-32. doi: 10.1385/ENDO:17:3:229.