PMID- 12109964
OWN - NLM
STAT- MEDLINE
DCOM- 20020910
LR  - 20061115
IS  - 1323-1316 (Print)
IS  - 1323-1316 (Linking)
VI  - 56
IP  - 4
DP  - 2002 Aug
TI  - Human leukocyte antigen alleles in patients with bipolar disorder in the Korean 
      population.
PG  - 453-7
AB  - We performed an association study between human leukocyte antigen (HLA) alleles 
      and bipolar disorder to evaluate the potentiality of HLA as a genetic marker in 
      bipolar disorder. HLA class I and class II allele frequencies were assessed in 87 
      bipolar patients and were compared with those of 206 normal controls in the 
      Korean population. HLA class I typing was performed using the 
      microlymphocytotoxicity method, whereas class II (DRB1 and DQB1) genotyping was 
      performed with polymerase chain reaction-sequence specific oligonucleotide 
      probes. When the allele frequency of HLA in bipolar patients was compared with 
      that in normal controls, there were some significant differences. Bipolar 
      patients showed statistically significant increased allele frequencies of HLA-A29 
      and B54. Allele frequencies of HLA-B51 and DRB1*02 were significantly higher in 
      normal controls. However, these results were no longer significant after 
      correcting for the number of alleles. The results of the present study suggest 
      that HLA alleles may not confer susceptibility to bipolar disorder in the Korean 
      population. To clarify the genetic influence of HLA on bipolar disorder, we 
      should conduct a consecutive study with a larger cohort of subjects.
FAU - Jun, Tae-youn
AU  - Jun TY
AD  - Department of Psychiatry, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Pae, Chi-un
AU  - Pae CU
FAU - Chae, Jeong-ho
AU  - Chae JH
FAU - Pyo, Chul-woo
AU  - Pyo CW
FAU - Han, Hoon
AU  - Han H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bipolar Disorder/*genetics
MH  - Female
MH  - *Gene Frequency
MH  - *Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction
EDAT- 2002/07/12 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/07/12 10:00
PHST- 2002/07/12 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/07/12 10:00 [entrez]
AID - 1035 [pii]
AID - 10.1046/j.1440-1819.2002.01035.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2002 Aug;56(4):453-7. doi: 
      10.1046/j.1440-1819.2002.01035.x.