PMID- 12110698
OWN - NLM
STAT- MEDLINE
DCOM- 20030108
LR  - 20071114
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 20
IP  - 4
DP  - 2002
TI  - Age-related alterations in the lymphohematopoietic and B-lineage precursor 
      populations in NZB mice.
PG  - 293-300
AB  - Significant disturbances in B lineage populations of New Zealand Black (NZB) mice 
      have been reported, both with respect to their phenotypes as well as to their 
      function. Notably, there is a profound age-dependent decrease in B-cell 
      precursors in this strain of lupus prone mice. In efforts to characterize the 
      impact of this disturbance in disease, we performed an intensive phenotypic and 
      B-cell population analysis in young and old NZB mice. Our results revealed that 
      there was a significant age-dependent decrease in B cell precursors at all levels 
      of the B-cell-lineage developmental pathway. Analysis of the proliferative 
      capacity of these cell populations showed a comparative decrease in cycling 
      activity in the B-cell-lineage populations of old NZB mice. Furthermore, these 
      cell subsets were much more susceptible to spontaneous apoptosis when compared 
      with similar populations from age-matched BALB/c or young NZB mice. Since the 
      frequency of cells that express the interleukin-7 receptor (IL-7R) declines as 
      NZB mice age, we hypothesize that impairment of IL-7R signal transduction 
      pathways could contribute to severe perturbations of B-cell function in aged NZB 
      mice.
FAU - Lian, Zhe-Xiong
AU  - Lian ZX
AD  - Division of Rheumatology/Allergy and Clinical Immunology, University of 
      California at Davis, Davis, California 95616, USA.
FAU - Okada, Tomoyuki
AU  - Okada T
FAU - Kita, Hiroto
AU  - Kita H
FAU - Hsu, Tom
AU  - Hsu T
FAU - Shultz, Leonard D
AU  - Shultz LD
FAU - Dorshkind, Kenneth
AU  - Dorshkind K
FAU - Ansari, Aftab A
AU  - Ansari AA
FAU - Naiki, Mitsuru
AU  - Naiki M
FAU - Ikehara, Susumu
AU  - Ikehara S
FAU - Gershwin, M Eric
AU  - Gershwin ME
LA  - eng
GR  - CA20408/CA/NCI NIH HHS/United States
GR  - CA20816/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Receptors, Interleukin-7)
SB  - IM
MH  - Aging/*immunology
MH  - Animals
MH  - Apoptosis/immunology
MH  - B-Lymphocytes/*cytology/physiology
MH  - Cell Division/*immunology
MH  - Cell Lineage/*physiology
MH  - Cell Survival/immunology
MH  - Down-Regulation/*immunology
MH  - Female
MH  - Hematopoietic Stem Cells/*cytology/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred NZB
MH  - Receptors, Interleukin-7/immunology
MH  - Signal Transduction/immunology
EDAT- 2002/07/12 10:00
MHDA- 2003/01/09 04:00
CRDT- 2002/07/12 10:00
PHST- 2002/07/12 10:00 [pubmed]
PHST- 2003/01/09 04:00 [medline]
PHST- 2002/07/12 10:00 [entrez]
AID - 10.1634/stemcells.20-4-293 [doi]
PST - ppublish
SO  - Stem Cells. 2002;20(4):293-300. doi: 10.1634/stemcells.20-4-293.