PMID- 12111481 OWN - NLM STAT- MEDLINE DCOM- 20020806 LR - 20151026 IS - 0300-9564 (Print) IS - 0300-9564 (Linking) VI - 109 IP - 5-6 DP - 2002 May TI - When cells become depressed: focus on neural stem cells in novel treatment strategies against depression. PG - 947-62 AB - Clinical neuroscience enters a new era in understanding the pathophysiology of depressive illness and the mode of action of antidepressant therapy. While elucidation of factors that lead to depression is still in its infancy, biochemical malfunctions appear to have well defined morphological correlations, especially in the hippocampus. Hippocampus is one of the main sites in the brain habouring neural stem cells. Cytokines and neurotrophic factors like brain-derived neurotrophic factor (BDNF) play a pivotal role in neural plasticity and potentially influence growth and migration of these progenitors. Not surprisingly, antidepressant drugs interfering with neurotransmitters such as serotonin (5-HT) influence neurotrophins like BDNF, since 5-HT homeostasis is essential for brain development, neurogenesis, and neuroplasticity as well as complex behavior. In this review, the new area of neural stem cell research and the avenues of ongoing and future research sustaining the development of novel treatments for depression will be explored. FAU - Benninghoff, J AU - Benninghoff J AD - Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Federal Republic of Germany. jens.benninghoff@mail.uni-wuerzburg.de FAU - Schmitt, A AU - Schmitt A FAU - Mossner, R AU - Mossner R FAU - Lesch, K-P AU - Lesch KP LA - eng PT - Journal Article PT - Review PL - Austria TA - J Neural Transm (Vienna) JT - Journal of neural transmission (Vienna, Austria : 1996) JID - 9702341 RN - 0 (Antidepressive Agents) SB - IM MH - Animals MH - Antidepressive Agents/adverse effects/therapeutic use MH - Depression/*physiopathology/*therapy MH - Hippocampus/physiopathology MH - Humans MH - Neurons/drug effects/*physiology MH - Stem Cell Transplantation MH - Stem Cells/*physiology RF - 78 EDAT- 2002/07/12 10:00 MHDA- 2002/08/07 10:01 CRDT- 2002/07/12 10:00 PHST- 2002/07/12 10:00 [pubmed] PHST- 2002/08/07 10:01 [medline] PHST- 2002/07/12 10:00 [entrez] AID - 10.1007/s007020200078 [doi] PST - ppublish SO - J Neural Transm (Vienna). 2002 May;109(5-6):947-62. doi: 10.1007/s007020200078.