PMID- 12111828
OWN - NLM
STAT- MEDLINE
DCOM- 20020814
LR  - 20161124
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 68
IP  - 6
DP  - 2002 Jun 15
TI  - Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine 
      adapters during retinal development: potential roles of N-Shc/ShcC in 
      brain-derived neurotrophic factor signal transduction and modulation.
PG  - 668-80
AB  - Neurotrophins (NTs) have multiple roles in retinal development and survival, 
      which are mediated through their specific receptors and signaling molecules. An 
      emerging family of adapter protein, Shc (Src homology and collagen)-related 
      molecules, i.e., Shc/ShcA, Sck/ShcB, and N-Shc/ShcC, has been implicated in 
      various phosphotyrosine signal transduction mechanisms, including that for NTs. 
      To explore the potential role(s) of Shc-related adapters in NT signaling in the 
      retina, we compared the developmental changes of the mRNA expression of TrkA -B, 
      and -C in the rat retina, on one hand and, on the other hand, studied which 
      members of the Shc family were activated after brain-derived neurotrophic factor 
      (BDNF) application in axotomized rat retinas. Early in development, both TrkA and 
      ShcA were highly expressed, whereas, in late development to adulthood, TrkB/C and 
      ShcB/C were highly expressed. In the mature retinal ganglion cell layer, the 
      expression of ShcB/C and TrkB/C was evident. Immunoreactivity of ShcC was located 
      in the retinal ganglion cells, amacrine cells, and inner plexiform layer. The 
      response of ShcC following retinal axotomy was most profound with the 
      administration of BDNF, and there was some response with neurotrophin-3. These 
      results indicate that ShcC could be a potential phosphotyrosine adapter among the 
      Shc family members for BDNF signaling and function during retinal development and 
      regeneration in vivo.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Nakazawa, Toru
AU  - Nakazawa T
AD  - Department of Molecular Genetics, National Institute for Longevity Sciences, 
      Aichi, Japan.
FAU - Nakano, Itsuko
AU  - Nakano I
FAU - Sato, Masahiro
AU  - Sato M
FAU - Nakamura, Takeshi
AU  - Nakamura T
FAU - Tamai, Makoto
AU  - Tamai M
FAU - Mori, Nozomu
AU  - Mori N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (SHC3 protein, human)
RN  - 0 (Shc Signaling Adaptor Proteins)
RN  - 0 (Shc1 protein, rat)
RN  - 0 (Shc2 protein, rat)
RN  - 0 (Shc3 protein, rat)
RN  - 0 (Src Homology 2 Domain-Containing, Transforming Protein 1)
RN  - 0 (Src Homology 2 Domain-Containing, Transforming Protein 2)
RN  - 0 (Src Homology 2 Domain-Containing, Transforming Protein 3)
RN  - 21820-51-9 (Phosphotyrosine)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Axotomy
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/metabolism/*pharmacology
MH  - Gene Expression Regulation
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Nerve Tissue Proteins/*analysis/drug effects/genetics
MH  - Neuropeptides/*metabolism
MH  - Phosphotyrosine/*metabolism
MH  - Plasmids
MH  - Precipitin Tests
MH  - Proteins/*analysis/drug effects/genetics
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rats, Wistar
MH  - Receptor, trkA/*analysis/genetics
MH  - Receptor, trkB/*analysis/genetics
MH  - Receptor, trkC/*analysis/genetics
MH  - Receptors, Nerve Growth Factor/metabolism
MH  - Retina/*growth & development/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Shc Signaling Adaptor Proteins
MH  - Signal Transduction
MH  - Src Homology 2 Domain-Containing, Transforming Protein 1
MH  - Src Homology 2 Domain-Containing, Transforming Protein 2
MH  - Src Homology 2 Domain-Containing, Transforming Protein 3
EDAT- 2002/07/12 10:00
MHDA- 2002/08/15 10:01
CRDT- 2002/07/12 10:00
PHST- 2002/07/12 10:00 [pubmed]
PHST- 2002/08/15 10:01 [medline]
PHST- 2002/07/12 10:00 [entrez]
AID - 10.1002/jnr.10259 [doi]
PST - ppublish
SO  - J Neurosci Res. 2002 Jun 15;68(6):668-80. doi: 10.1002/jnr.10259.