PMID- 12112780
OWN - NLM
STAT- MEDLINE
DCOM- 20020920
LR  - 20191210
IS  - 8755-6863 (Print)
IS  - 1099-0496 (Linking)
VI  - 34
IP  - 2
DP  - 2002 Aug
TI  - Increased interleukin-8 and monocyte chemoattractant protein-1 concentrations in 
      mechanically ventilated preterm infants with pulmonary hemorrhage.
PG  - 131-7
AB  - Pulmonary hemorrhage (PH) is a serious complication causing acute respiratory 
      distress in the premature infant, and it is associated with significant mortality 
      and morbidity. The role of inflammatory mediators in this condition is largely 
      undefined. Serial tracheal aspirates (TA) were obtained at intervals from 65 
      mechanically ventilated infants with birth weights less than 1,250 g during the 
      first 21 days of life. Clinically significant PH developed in 15 infants. TA 
      concentrations of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 
      (MCP-1) were determined by enzyme-linked immunosorbent assay (ELISA).PH was 
      associated with an increased risk of death, bronchopulmonary dysplasia, 
      intraventricular hemorrhage, and prolonged need for mechanical ventilation and 
      supplemental oxygen. TA aspirate concentrations of IL-8 and MCP-1 (P = 0.001, 
      ANOVA) were significantly increased in infants with PH compared to infants who 
      did not develop this condition. TA cytokine concentrations were also 
      significantly increased in infants who developed bronchopulmonary dysplasia 
      (BPD). Peak TA concentrations of IL-8 and MCP-1 were significantly higher in 
      infants with poor outcome (BPD or death). TA MCP-1 but not IL-8 concentrations 
      were significantly higher in infants who were oxygen-dependent at 36 weeks 
      postconceptional age. These data suggest a pathogenic role for IL-8 and MCP-1 in 
      the development of adverse pulmonary outcome in preterm infants with clinically 
      significant PH.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Baier, R John
AU  - Baier RJ
AD  - Department of Pediatrics, Louisiana State University Health Sciences Center, 
      Shreveport 71130-3932, USA. jbaier@lsuhsc.edu
FAU - Loggins, John
AU  - Loggins J
FAU - Kruger, Thomas E
AU  - Kruger TE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Chemokine CCL2/*analysis
MH  - Hemorrhage/*immunology/mortality/*therapy
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/*immunology
MH  - Infant, Very Low Birth Weight/immunology
MH  - Interleukin-8/*analysis
MH  - Lung Diseases/*immunology/mortality/*therapy
MH  - Outcome Assessment, Health Care
MH  - Predictive Value of Tests
MH  - *Respiration, Artificial
MH  - Suction
MH  - Trachea/*chemistry/*immunology
EDAT- 2002/07/12 10:00
MHDA- 2002/09/21 10:01
CRDT- 2002/07/12 10:00
PHST- 2002/07/12 10:00 [pubmed]
PHST- 2002/09/21 10:01 [medline]
PHST- 2002/07/12 10:00 [entrez]
AID - 10.1002/ppul.10141 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2002 Aug;34(2):131-7. doi: 10.1002/ppul.10141.