PMID- 12112936
OWN - NLM
STAT- MEDLINE
DCOM- 20030103
LR  - 20220310
IS  - 1520-7552 (Print)
IS  - 1520-7552 (Linking)
VI  - 18
IP  - 3
DP  - 2002 May-Jun
TI  - Brain-derived neurotrophic factor (BDNF) regulates glucose and energy metabolism 
      in diabetic mice.
PG  - 185-91
AB  - Neurotrophins are important regulators in the embryogenesis, development and 
      functioning of nervous systems. In addition to the efficacy of brain-derived 
      neurotrophic factor (BDNF) in neurological disorders, we have found that BDNF 
      demonstrates endocrinological functions and reduces food intake and blood glucose 
      concentration in rodent obese diabetic models, such as C57BL/KsJ-db/db mice. The 
      hypoglycemic effect of BDNF was found to be stronger in younger db/db mice with 
      hyperinsulinemia than in older mice. While BDNF itself did not alter blood 
      glucose in normal mice and streptozotocin (STZ)-treated mice, BDNF enhanced the 
      hypoglycemic effect of insulin in STZ-treated mice. These data indicate that BDNF 
      needs endogenous or exogenous insulin to show hypoglycemic action. In addition, 
      BDNF treatment enhanced energy expenditure in db/db mice. The efficacy of BDNF in 
      regulating glucose and energy metabolism was reproduced through 
      intracerebroventricular administration, suggesting that BDNF acted directly on 
      the hypothalamus, the autonomic center of the brain.
CI  - Copyright 2002 John Wiley & Sons, Ltd.
FAU - Nakagawa, Tsutomu
AU  - Nakagawa T
AD  - Sumitomo Pharmaceuticals Co. Ltd, Discovery Research Laboratories II, Osaka, 
      Japan.
FAU - Ono-Kishino, Michiko
AU  - Ono-Kishino M
FAU - Sugaru, Eiji
AU  - Sugaru E
FAU - Yamanaka, Mitsugu
AU  - Yamanaka M
FAU - Taiji, Mutsuo
AU  - Taiji M
FAU - Noguchi, Hiroshi
AU  - Noguchi H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Diabetes Mellitus/blood/*metabolism
MH  - Diabetes Mellitus, Experimental/blood/*metabolism
MH  - *Energy Metabolism
MH  - Glucose/*metabolism
MH  - Hyperglycemia/metabolism
MH  - Mice
MH  - *Obesity
RF  - 44
EDAT- 2002/07/12 10:00
MHDA- 2003/01/04 04:00
CRDT- 2002/07/12 10:00
PHST- 2002/07/12 10:00 [pubmed]
PHST- 2003/01/04 04:00 [medline]
PHST- 2002/07/12 10:00 [entrez]
AID - 10.1002/dmrr.290 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2002 May-Jun;18(3):185-91. doi: 10.1002/dmrr.290.