PMID- 12113287
OWN - NLM
STAT- MEDLINE
DCOM- 20030703
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 40
IP  - 5
DP  - 2002 May
TI  - An evaluation of antiretroviral therapy associated with alpha-tocopherol 
      supplementation in HIV-infected patients.
PG  - 456-9
AB  - In HIV-infected patients, an increase in the production of oxygen-reactive 
      species (ROS) is observed, with a consequent reduction of plasma levels of 
      antioxidants such as alpha-tocopherol. The nuclear transcription factor-kappaB 
      (NF-kappaB) is activated by a prooxidant state in the infected T cells through 
      the release of its inhibitory subunit I-kappaB. The aim of the present work was 
      to evaluate the behavior of hematological parameters and markers of anemia in 
      HIV-infected patients who underwent antiretroviral therapy associated with 800 
      mg/day alpha-tocopherol supplementation. Blood samples were collected from 
      supplemented (n=9) and not-supplemented (n=9) HIV-seropositive patients (n=18). 
      We observed a decreased viral load in the alpha-tocopherol-supplemented group 
      (p<0.05); other changes, such as an increase in the CD4/CD8 ratio, in the 
      hematocrit and in the hemoglobin concentration were also observed, though lacking 
      statistical significance. We conclude that antiretroviral therapy in association 
      with alpha-tocopherol (800 mg/day) supplementation is more effective in reducing 
      viral load levels and also, possibly, in recovering other hematological 
      parameters after a 60-day period of use.
FAU - Spada, Celso
AU  - Spada C
AD  - UFSC Clinical Analysis Department, Centro de Ciencias de Saude, Universidade 
      Federal de Santa Catarina, Florianopolis, Brazil. celso@ccs.ufsc.br
FAU - Treitinger, Aricio
AU  - Treitinger A
FAU - Reis, Marcellus
AU  - Reis M
FAU - Masokawa, Ivete Y
AU  - Masokawa IY
FAU - Verdi, Julio C
AU  - Verdi JC
FAU - Luiz, Magali C
AU  - Luiz MC
FAU - Silveira, Mariete V S
AU  - Silveira MV
FAU - Oliveira, Osvaldo V
AU  - Oliveira OV
FAU - Michelon, Cleonice M
AU  - Michelon CM
FAU - Avila-Junior, Silvio
AU  - Avila-Junior S
FAU - Gil, lone D O
AU  - Gil lD
FAU - Ostrowsky, Stephanie
AU  - Ostrowsky S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Hemoglobins)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Anemia/blood/diagnosis/drug therapy
MH  - Anti-HIV Agents/*administration & dosage
MH  - Antioxidants/*administration & dosage
MH  - CD4-CD8 Ratio
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - HIV Infections/blood/complications/*drug therapy
MH  - Hematocrit
MH  - Hemoglobins/drug effects/metabolism
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Viral Load
MH  - alpha-Tocopherol/*administration & dosage
EDAT- 2002/07/13 10:00
MHDA- 2003/07/04 05:00
CRDT- 2002/07/13 10:00
PHST- 2002/07/13 10:00 [pubmed]
PHST- 2003/07/04 05:00 [medline]
PHST- 2002/07/13 10:00 [entrez]
AID - 10.1515/CCLM.2002.078 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2002 May;40(5):456-9. doi: 10.1515/CCLM.2002.078.