PMID- 12114907
OWN - NLM
STAT- MEDLINE
DCOM- 20020801
LR  - 20190616
IS  - 0002-9378 (Print)
IS  - 0002-9378 (Linking)
VI  - 187
IP  - 1
DP  - 2002 Jul
TI  - Fetal umbilical vascular response to chronic reductions in uteroplacental blood 
      flow in late-term sheep.
PG  - 178-86
AB  - OBJECTIVE: The present study was designed to determine the effects of chronic 
      reduction in uterine blood flow (UBF) on umbilical blood flow (UmbBF) and fetal 
      cardiovascular hemodynamics and oxygenation. STUDY DESIGN: Sixteen sheep with 
      singleton pregnancies were instrumented on gestational day (GD) 110; an 
      externally adjustable vascular occluder was placed on the common internal iliac 
      artery. UBF in control animals rose from 867 +/- 61 mL/min on GD 115 to 1520 +/- 
      158 mL/min (n = 8) on GD 138, whereas UBF in restricted animals was maintained at 
      750 +/- 50 mL/min (n = 8). RESULTS: UmbBF in control animals increased from 472 
      +/- 25 mL/min to 744 +/- 58 mL/min over the study period from GD 115 to GD 138. 
      This was associated with normal gestational increases in fetal arterial pressure 
      and significant reductions in calculated umbilical vascular resistance. Although 
      restricted animals initially had a similar UmbBF on GD 115, UmbBF rose only to 
      545 +/- 43 mL/min over the study period (control vs restricted, P <.008). 
      Although fetal arterial pressure showed normal gestational changes, umbilical 
      vascular resistance failed to decrease over gestation in restricted animals as it 
      did in control animals. Fetal heart rate and oxygenation showed normal changes in 
      both groups. CONCLUSION: Chronic reduction in UBF prevents umbilical vascular 
      resistance from undergoing normal gestational decreases, leading to significantly 
      lower UmbBF. This altered umbilical perfusion pattern would be expected to 
      significantly affect fetal delivery of oxygen and nutrients and ultimately fetal 
      growth.
FAU - Lang, Uwe
AU  - Lang U
AD  - Department of Obstetrics and Gynecology, Justus-Liebig University Giessen, 
      Germany.
FAU - Baker, R Scott
AU  - Baker RS
FAU - Khoury, Jane
AU  - Khoury J
FAU - Clark, Kenneth E
AU  - Clark KE
LA  - eng
GR  - HD-18370/HD/NICHD NIH HHS/United States
GR  - HD-20748/HD/NICHD NIH HHS/United States
GR  - HL-49901/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Female
MH  - Fetus/*physiology
MH  - Gestational Age
MH  - Heart Rate, Fetal
MH  - Hemodynamics
MH  - Placenta/*blood supply
MH  - Pregnancy
MH  - Sheep
MH  - Umbilical Arteries/*physiology
MH  - Uterus/*blood supply
EDAT- 2002/07/13 10:00
MHDA- 2002/08/02 10:01
CRDT- 2002/07/13 10:00
PHST- 2002/07/13 10:00 [pubmed]
PHST- 2002/08/02 10:01 [medline]
PHST- 2002/07/13 10:00 [entrez]
AID - S000293780200100X [pii]
AID - 10.1067/mob.2002.122849 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2002 Jul;187(1):178-86. doi: 10.1067/mob.2002.122849.