PMID- 12115033
OWN - NLM
STAT- MEDLINE
DCOM- 20030812
LR  - 20061115
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 13
IP  - 6
DP  - 2002 Jun
TI  - Detailed chromosomal and radiation hybrid mapping in the proximal part of rat 
      Chromosome 10 and gene order comparison with mouse and human.
PG  - 302-9
AB  - The rat provides valuable and sometimes unique models of human complex diseases. 
      To fully exploit the rat models in biomedical research, it is important to have 
      access to detailed knowledge of the rat genome organization as well as its 
      relation to the human genome. Rat Chromosome 10 (RNO10) harbors several important 
      cancer-related genes. Deletions in the proximal part of RNO10 were repeatedly 
      found in a rat model for endometrial cancer. To identify functional and 
      positional candidate genes in the affected region, we used radiation hybrid (RH) 
      mapping and single- and dual-color fluorescence in situ hybridization (FISH) 
      techniques to construct a detailed chromosomal map of the proximal part of RNO10. 
      The regional localization of 14 genes, most of them cancer-related ( Grin2a, 
      Gspt1, Crebbp, Gfer, Tsc2, Tpsb1, Il9r, Il4, Irf1, Csf2, Sparc, Tp53, Thra1, 
      Gh1), and of five microsatellite markers ( D10Mit10, D10Rat42, D10Rat50, 
      D10Rat72, and D10Rat165) was determined on RNO10. For a fifteenth gene, Ppm1b, 
      which had previously been assigned to RNO10, the map position was corrected to 
      RNO6q12-q13.
FAU - Behboudi, Afrouz
AU  - Behboudi A
AD  - Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Goteborg 
      University, Box 462, Sweden. Afrouz.Behboudi@gen.gu.se
FAU - Roshani, Leyla
AU  - Roshani L
FAU - Kost-Alimova, Marija
AU  - Kost-Alimova M
FAU - Sjostrand, Eleonor
AU  - Sjostrand E
FAU - Montelius-Alatalo, Kerstin
AU  - Montelius-Alatalo K
FAU - Rohme, Dan
AU  - Rohme D
FAU - Klinga-Levan, Karin
AU  - Klinga-Levan K
FAU - Stahl, Fredrik
AU  - Stahl F
LA  - eng
SI  - GENBANK/AF410807
SI  - GENBANK/AF410808
SI  - GENBANK/AF410809
SI  - GENBANK/AF410811
SI  - GENBANK/AF447453
SI  - GENBANK/AF447454
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
SB  - IM
MH  - Animals
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Microsatellite Repeats
MH  - Molecular Sequence Data
MH  - *Radiation Hybrid Mapping
MH  - Rats
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Synteny
EDAT- 2002/07/13 10:00
MHDA- 2003/08/13 05:00
CRDT- 2002/07/13 10:00
PHST- 2001/11/29 00:00 [received]
PHST- 2002/01/23 00:00 [accepted]
PHST- 2002/07/13 10:00 [pubmed]
PHST- 2003/08/13 05:00 [medline]
PHST- 2002/07/13 10:00 [entrez]
AID - 10.1007/s00335-001-2153-4 [doi]
PST - ppublish
SO  - Mamm Genome. 2002 Jun;13(6):302-9. doi: 10.1007/s00335-001-2153-4.