PMID- 12115843
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20181130
IS  - 0022-3549 (Print)
IS  - 0022-3549 (Linking)
VI  - 91
IP  - 6
DP  - 2002 Jun
TI  - Face specific surface properties of pharmaceutical crystals.
PG  - 1432-44
AB  - A variety of surface specific techniques have been used to determine the 
      face-specific structure, chemistry, and wettability of model pharmaceutical 
      crystals, i.e., N,n-octyl-d-gluconamide and sulfathiazole (polymorphic forms I 
      and III). The surface energetics of individual crystal faces were investigated by 
      studying their wetting characteristics and interaction with chemically modified 
      silica spheres using colloid probe atomic force microscopy (AFM). Contact angles 
      (dynamic and static), interaction forces, and adhesion properties have been shown 
      to correlate strongly with the face specific surface chemistry. This, in turn, is 
      controlled by the molecular arrangement at the specific crystal face, which has 
      been characterized by time-of-flight secondary-ion mass spectrometry (ToF SIMS) 
      and inferred from molecular models. Of specific note, the magnitude of the 
      adhesion force between a crystal face and a hydrophobic colloid probe is related 
      linearly to the face-specific equilibrium contact angle. These studies further 
      our understanding of the face-specific properties of pharmaceutical crystals and 
      have implications when considering processing, formulation and delivery.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Muster, Tim H
AU  - Muster TH
AD  - Ian Wark Research Institute, University of South Australia, Mawson Lakes, SA 
      5095, Australia.
FAU - Prestidge, Clive A
AU  - Prestidge CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Gluconates)
RN  - 0 (N,n-octyl-gluconamide)
RN  - 0 (Sulfathiazoles)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - Y7FKS2XWQH (Sulfathiazole)
SB  - IM
MH  - Chemical Phenomena
MH  - Chemistry, Physical
MH  - Crystallization
MH  - Gluconates/*chemistry
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Microscopy, Atomic Force
MH  - Silicon Dioxide/*chemistry
MH  - Sulfathiazole
MH  - Sulfathiazoles/*chemistry
MH  - Surface Properties
MH  - Wettability
EDAT- 2002/07/13 10:00
MHDA- 2002/10/09 04:00
CRDT- 2002/07/13 10:00
PHST- 2002/07/13 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/07/13 10:00 [entrez]
AID - S0022-3549(16)31011-5 [pii]
AID - 10.1002/jps.10125 [doi]
PST - ppublish
SO  - J Pharm Sci. 2002 Jun;91(6):1432-44. doi: 10.1002/jps.10125.