PMID- 12118860
OWN - NLM
STAT- MEDLINE
DCOM- 20030116
LR  - 20230124
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 2
IP  - 4
DP  - 2002 Apr
TI  - A comparison between recipients receiving matched kidney and those receiving 
      mismatched kidney from the same cadaver donor.
PG  - 366-72
AB  - The optimal allocation of cadaveric kidneys for transplantation with reference to 
      human leukocyte antigen (HLA) match and sharing these organs to a distant center 
      remains controversial. The current analysis was performed using the United 
      Network for Organ Sharing (UNOS) database for cadaveric kidney transplants (Tx) 
      between 1988 and 1997. The graft survivals of zero-mismatch (matched) kidneys 
      with the mate (mismatched) kidneys were compared. There were 2385 donors and 4770 
      Tx. Significant differences in recipient demographics between matched and 
      mismatched Tx were: fewer African-American race (AA) in the matched group (9.0% 
      vs. 21.9%), higher number of previous Tx (25.5% vs. 14.8%) and elevated mean cold 
      ischemia time (24.0 vs. 22.2 h). Post-Tx dialysis requirements were similar 
      (22.8% vs. 24.1%, p = 0.62) and matched kidneys had to travel more distance (920 
      vs. 232 miles). Using a Cox model, the matched group had a decreased relative 
      hazard of graft failure of 23.0% (p = 0.0002) or 35% (p < 0.0001) with and 
      without censoring for death. There was significantly better graft survival in the 
      matched recipients in all pairs except AA (matched) and non-AA (mismatched). For 
      older donors (> or = 50 years, n = 1508), the matched grafts survival was 
      marginally significant (p =0.05). Matched kidneys have improved survival compared 
      with the mismatched kidneys despite the longer distance traveled. The benefit of 
      mismatched transplants was predominantly seen in non-AA.
FAU - Bresnahan, Barbara A
AU  - Bresnahan BA
AD  - Division of Nephrology, Medical College of Wisconsin, Milwaukee, USA. 
      bbresnah@mcw.edu
FAU - Johnson, Christopher P
AU  - Johnson CP
FAU - McIntosh, Matthew J
AU  - McIntosh MJ
FAU - Stablein, Donald
AU  - Stablein D
FAU - Hariharan, Sundaram
AU  - Hariharan S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Am J Transplant. 2002 Apr;2(4):295-6. PMID: 12118848
MH  - Adolescent
MH  - Adult
MH  - Cadaver
MH  - Female
MH  - Graft Rejection
MH  - *Graft Survival
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility
MH  - Humans
MH  - Kidney Transplantation/*immunology/*methods
MH  - Male
MH  - Middle Aged
MH  - Organ Preservation
MH  - Proportional Hazards Models
MH  - Temperature
MH  - Time Factors
MH  - *Tissue Donors
MH  - Transplantation, Homologous
MH  - Travel
EDAT- 2002/07/18 10:00
MHDA- 2003/01/17 04:00
CRDT- 2002/07/18 10:00
PHST- 2002/07/18 10:00 [pubmed]
PHST- 2003/01/17 04:00 [medline]
PHST- 2002/07/18 10:00 [entrez]
AID - S1600-6135(22)07383-X [pii]
AID - 10.1034/j.1600-6143.2002.20413.x [doi]
PST - ppublish
SO  - Am J Transplant. 2002 Apr;2(4):366-72. doi: 10.1034/j.1600-6143.2002.20413.x.