PMID- 12119481
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20180213
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 91
IP  - 3
DP  - 2002 Jul
TI  - Effects of oral adsorbent AST-120 (Kremezin) on renal function and glomerular 
      injury in early-stage renal failure of subtotal nephrectomized rats.
PG  - 480-5
AB  - The aim of the present study was to determine if treatment with an oral adsorbent 
      (AST-120, Kremezin) might decrease the urinary albumin excretion and serum 
      indoxyl sulfate (s-IS), and prevent glomerular sclerosis in early-stage renal 
      failure, i.e. 0.9-1.2 mg/dl of serum creatinine (s-Cr) and 60-95 mg/dl of blood 
      urea nitrogen (BUN), in subtotal (3/4) nephrectomized rats. Levels of s-Cr and 
      s-IS in the AST-120-treated rats were significantly lower than those in the 
      untreated control rats. The AST-120-treated rats showed an increase of creatinine 
      clearance. Urinary protein and indoxyl sulfate excretion in the AST-120-treated 
      rats were also significantly lower than those in the untreated control rats. The 
      ratio of glomerular tuft area to the area of Bowman's capsules (GT/BC) in the 
      AST-120-treated rats was significantly lower than that in the untreated control 
      rats. The degree of glomerular sclerosis and tubulointerstitial fibrosis in the 
      AST-120-treated rats was significantly lower than that in the untreated control 
      rats. Furthermore, there was a significant relationship among the degree of 
      GT/BC, glomerular sclerosis, tubulointerstitial fibrosis and the levels of 
      urinary protein excretion. It appears that AST-120 might decrease the 
      accumulation of s-Cr and s-IS, and prevent glomerular sclerosis in early stage 
      renal failure in the subtotal nephrectomized rats.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Kobayashi, Noriyoshi
AU  - Kobayashi N
AD  - Division of Nephrology, Department of Internal Medicine, Juntendo University 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
FAU - Maeda, Atsuko
AU  - Maeda A
FAU - Horikoshi, Satoshi
AU  - Horikoshi S
FAU - Shirato, Isao
AU  - Shirato I
FAU - Tomino, Yasuhiko
AU  - Tomino Y
FAU - Ise, Michihito
AU  - Ise M
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Oxides)
RN  - 7440-44-0 (Carbon)
RN  - 90597-58-3 (AST 120)
RN  - AYI8EX34EU (Creatinine)
RN  - N187WK1Y1J (Indican)
SB  - IM
MH  - Adsorption
MH  - Animals
MH  - Blood Pressure/physiology
MH  - Blood Urea Nitrogen
MH  - Carbon/*pharmacology
MH  - Creatinine/blood
MH  - Fibrosis/pathology
MH  - Indican/blood/urine
MH  - Kidney/anatomy & histology/*drug effects/metabolism/pathology
MH  - Kidney Glomerulus/*drug effects/metabolism/pathology
MH  - Male
MH  - Nephrectomy
MH  - Oxides/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Renal Insufficiency/*physiopathology
MH  - Sclerosis/pathology
EDAT- 2002/07/18 10:00
MHDA- 2003/03/04 04:00
CRDT- 2002/07/18 10:00
PHST- 2002/07/18 10:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2002/07/18 10:00 [entrez]
AID - nef91480 [pii]
AID - 10.1159/000064291 [doi]
PST - ppublish
SO  - Nephron. 2002 Jul;91(3):480-5. doi: 10.1159/000064291.