PMID- 12120693
OWN - NLM
STAT- MEDLINE
DCOM- 20030114
LR  - 20170214
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 8
IP  - 3
DP  - 2002 May
TI  - Cerebral blood flow velocity changes to visual stimuli in patients with multiple 
      sclerosis.
PG  - 217-21
AB  - We assessed the blood flow velocity (BFv) changes to visual stimuli using 
      transcranial Doppler (TCD) in patients with multiple sclerosis (MS) during an 
      exacerbation period by means of vasoneuronal coupling. Eighty-four patients (19 
      men, 75 women) and 45 healthy subjects (14 men, 31 women) were studied. Both 
      posterior cerebral arteries (PCAs) were simultaneously monitored by TCD 
      sonography during 10 cycles of 20 s eyes open observing complex moving visual 
      images, and 20 s eyes closed at the end of every cycle. TCD sonography was 
      performed at least at the first 2 days of exacerbation. Mean cerebral BFv 
      throughout the procedure (p=0.003, p=0.001; right and left sides, respectively), 
      velocity at rest (p=0.001, p<0.001), and velocity at stimulation (p=0.021, 
      p=0.01) on both PCAs were significantly lower in patients than controls. However, 
      BFv changes to visual stimulation on both sides were significantly higher in 
      patients (p=0.01, p=0.031) compared to controls. There were negative correlations 
      between P100 latencies and relative blood flow changes on both sides, but it was 
      not significant on the left side. These results may suggest that patients with MS 
      during exacerbation have more reactive vessels in the posterior circulation and! 
      or more reactive neurons in the occipital cortex.
FAU - Uzuner, N
AU  - Uzuner N
AD  - Department of Neurology, Faculty of Medicine, Osmangazi University, Eskisehir, 
      Turkey. nuzuner@ogu.edu.tr
FAU - Ozkan, S
AU  - Ozkan S
FAU - Gucuyener, D
AU  - Gucuyener D
FAU - Ozdemir, G
AU  - Ozdemir G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Adult
MH  - *Cerebrovascular Circulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnostic imaging/*physiopathology
MH  - Photic Stimulation
MH  - Reaction Time
MH  - Ultrasonography, Doppler, Transcranial
EDAT- 2002/07/18 10:00
MHDA- 2003/01/15 04:00
CRDT- 2002/07/18 10:00
PHST- 2002/07/18 10:00 [pubmed]
PHST- 2003/01/15 04:00 [medline]
PHST- 2002/07/18 10:00 [entrez]
AID - 10.1191/1352458502ms798oa [doi]
PST - ppublish
SO  - Mult Scler. 2002 May;8(3):217-21. doi: 10.1191/1352458502ms798oa.