PMID- 12120939
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20190901
IS  - 0300-8126 (Print)
IS  - 0300-8126 (Linking)
VI  - 30
IP  - 3
DP  - 2002 Jun
TI  - Multiple sclerosis and human herpesvirus 6.
PG  - 145-9
AB  - BACKGROUND: A possible but as yet unproven relationship has been proposed between 
      the onset or persistence of multiple sclerosis (MS) symptoms and herpesviruses, 
      including, most recently, human herpesvirus 6 (HHV-6). A study was conducted to 
      investigate the presence of HHV-6 DNA and the synthesis of antibodies against 
      HHV-6, cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in serum and 
      cerebrospinal fluid (CSF) of patients with MS. MATERIALS AND METHODS: PCR and 
      ELISA were used to detect HHV-6 DNA and specific antibodies against HHV-6, CMV 
      and EBV in 211 samples (139 sera and 72 CSF). There were three groups of samples: 
      group I, paired samples of serum and CSF from 41 MS patients; group II, paired 
      samples of serum and CSF from 31 patients with neurological diseases other than 
      MS (OND); group III, 67 serum samples from 27 different MS patients undergoing 
      serologic follow-up. RESULTS: No HHV-6 DNA was found in any sample. Group I sera 
      showed elevated anti-HHV-6 IgG and IgA levels. In group II, anti-CMV IgG was 
      detected in one CSF sample and anti-HHV-6 IgM in one serum sample. Group III sera 
      showed high concentrations of anti-HHV-6 IgG, IgA and IgM. CONCLUSION: Given the 
      clinical implications of the presence of antibodies against HHV-6 in MS patients, 
      a viral reactivation cannot be excluded as an environmental factor.
FAU - Gutierrez, J
AU  - Gutierrez J
AD  - Dept. of Microbiology, Faculty of Medicine, University Hospital San Cecilio, 
      Granada, Spain. josegf@ugr.es
FAU - Vergara, M J
AU  - Vergara MJ
FAU - Guerrero, M
AU  - Guerrero M
FAU - Fernandez, O
AU  - Fernandez O
FAU - Piedrola, G
AU  - Piedrola G
FAU - Morales, P
AU  - Morales P
FAU - Maroto, M C
AU  - Maroto MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
RN  - 0 (Antibodies, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*analysis
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Confidence Intervals
MH  - Cytomegalovirus/*isolation & purification
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Herpesvirus 4, Human/*isolation & purification
MH  - Herpesvirus 6, Human/*immunology/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/blood/cerebrospinal fluid/*epidemiology
MH  - RNA, Viral/analysis
MH  - Reference Values
MH  - Roseolovirus Infections/blood/*epidemiology
MH  - Sampling Studies
MH  - Sensitivity and Specificity
MH  - Spain/epidemiology
MH  - Statistics, Nonparametric
EDAT- 2002/07/18 10:00
MHDA- 2003/01/11 04:00
CRDT- 2002/07/18 10:00
PHST- 2002/07/18 10:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/07/18 10:00 [entrez]
AID - 10.1007/s15010-002-2056-7 [doi]
PST - ppublish
SO  - Infection. 2002 Jun;30(3):145-9. doi: 10.1007/s15010-002-2056-7.