PMID- 12121679
OWN - NLM
STAT- MEDLINE
DCOM- 20030130
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 63
IP  - 8
DP  - 2002 Aug
TI  - Association between interleukin-6 gene polymorphism and human T-cell leukemia 
      virus type I associated myelopathy.
PG  - 696-700
AB  - We studied cytokine gene polymorphisms in the promoter region, including 
      interleukin (IL)-6, IL-1beta, and IL-10, in Japanese patients with human T-cell 
      leukemia virus type I (HTLV-I) associated myelopathy (HAM) (n = 65), asymptomatic 
      HTLV-I carriers (n = 143), and HTLV-I seronegative, normal controls (n = 160). 
      There was a significant difference between HAM patients and HTLV-I carriers in 
      the distribution of IL-6 promoter polymorphism at position -634 (chi(2) = 9.90, p 
      = 0.0071). The IL-6 genotype was also significantly different between HAM 
      patients and normal controls (chi(2) = 11.53, p = 0.0033), while a similar 
      distribution was observed in IL-1beta and IL-10 polymorphisms among HAM patients, 
      carriers, and normal controls. The results suggest that IL-6 gene region may 
      contribute to susceptibility to HAM, and that aberrant cytokine productions could 
      be involved in the development of HAM.
FAU - Nishimura, Masataka
AU  - Nishimura M
AD  - Department of Clinical Neuroscience,Tokushima, Japan. 
      m_nishim@clin.med.tokushima-u.ac.jp
FAU - Matsuoka, Masao
AU  - Matsuoka M
FAU - Maeda, Michiyuki
AU  - Maeda M
FAU - Mizuta, Ikuko
AU  - Mizuta I
FAU - Mita, Shuji
AU  - Mita S
FAU - Uchino, Makoto
AU  - Uchino M
FAU - Matsui, Makoto
AU  - Matsui M
FAU - Kuroda, Yasuo
AU  - Kuroda Y
FAU - Kawakami, Hideshi
AU  - Kawakami H
FAU - Kaji, Ryuji
AU  - Kaji R
FAU - Adachi, Akio
AU  - Adachi A
FAU - Uchiyama, Takashi
AU  - Uchiyama T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Carrier State/immunology
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Humans
MH  - Interleukin-1/genetics
MH  - Interleukin-10/genetics
MH  - Interleukin-6/*genetics
MH  - Japan
MH  - Paraparesis, Tropical Spastic/etiology/*genetics/*immunology
MH  - *Polymorphism, Genetic
EDAT- 2002/07/18 10:00
MHDA- 2003/01/31 04:00
CRDT- 2002/07/18 10:00
PHST- 2002/07/18 10:00 [pubmed]
PHST- 2003/01/31 04:00 [medline]
PHST- 2002/07/18 10:00 [entrez]
AID - S0198885902004196 [pii]
AID - 10.1016/s0198-8859(02)00419-6 [doi]
PST - ppublish
SO  - Hum Immunol. 2002 Aug;63(8):696-700. doi: 10.1016/s0198-8859(02)00419-6.