PMID- 12126569
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20111117
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 37
IP  - 6
DP  - 2002 Jun 18
TI  - [Study on polymorphism of human leukocyte antigen-DRB1 allele in patients with 
      endometriosis].
PG  - 346-8
AB  - OBJECTIVE: To study the possibility of a correlation between occurrence of 
      endometriosis (EM) and polymorphism of human leukocyte antigen (HLA) DRB1 allele. 
      METHODS: Polymorphism of HLA-DRB1 allele were detected by polymerase chain 
      reaction- sequence specific primers (PCR-SSP) testing 40 surgically proven EM 
      patients and 50 normal control. RESULTS: At HLA-DRB1 15 allele, positive 
      frequency of EM group was significant higher as compared with those of the normal 
      control group [45.0% vs 26.0%, P < 0.05, relative risk (RR) = 2.1]. Other 
      HLA-DRB1 allele positive frequency of EM group and control group had no 
      significant difference. But for Polymorphism of DRB1 * 15 allele, positive 
      frequency of EM group and control group had no significant difference [1501 : 
      35.0% vs 20.0%; 1502 : 10.0% vs 6.0%; P > 0.05]. CONCLUSIONS: The occurrence of 
      EM may be associated with the presence of HLA-DRB1 allele, but hasn't associated 
      about polymorphism of DRB1* 15 allele. HLA-DRB1 * 15 maybe one of some factors 
      for the pathogenesis of endometriosis.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South 
      University, Changsha 410011, China.
FAU - Liu, Chunyu
AU  - Liu C
FAU - Lin, Qiuhua
AU  - Lin Q
FAU - Fang, Xiaoling
AU  - Fang X
FAU - Lin, Li
AU  - Lin L
FAU - Mei, Qiyuan
AU  - Mei Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Endometriosis/*genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - *Polymorphism, Genetic
EDAT- 2002/07/20 10:00
MHDA- 2005/01/26 09:00
CRDT- 2002/07/20 10:00
PHST- 2002/07/20 10:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2002/07/20 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2002 Jun 18;37(6):346-8.