PMID- 12127475
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20190826
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 110
IP  - 3
DP  - 2002 Jul 31
TI  - Decreased levels of brain-derived neurotrophic factor in serum of chronic 
      schizophrenic patients.
PG  - 249-57
AB  - Neurotrophic factors regulate neuronal development as well as synaptic 
      plasticity, and their impairment is often implicated as a cause of schizophrenia. 
      Among various neurotrophic molecules, brain-derived neurotrophic factor (BDNF) 
      levels have been found to be increased in the corticolimbic regions of patients' 
      brains. In the present study, we assessed peripheral BDNF levels in whole blood 
      as well as in the serum of two independent groups of schizophrenic patients (n = 
      34 in each group) and healthy volunteers (n = 35 and n = 27, respectively). BDNF 
      protein levels in fresh serum and blood of the patients and volunteers were 
      measured using a two-site enzyme immunoassay and correlated with the number and 
      decay of platelets. In addition to the studies of patients and volunteers, 
      neuroleptic effects on BDNF levels were assessed by administering haloperidol to 
      adult rats for 2 weeks or 5 months. The major findings were as follows: BDNF 
      levels were significantly reduced in the serum of schizophrenic patients (P < 
      0.005, Mann-Whitney U-test) but not in their whole blood. Antipsychotic dose did 
      not correlate with serum BDNF levels. Moreover, chronic administration of 
      haloperidol failed to decrease serum BDNF levels in adult rats. Abnormal levels 
      of BDNF are evident not only in the brain of schizophrenic patients, but also in 
      their peripheral blood. The BDNF reduction in serum but not in whole blood 
      suggests a potential deficit in neurotrophic factor release in patients with 
      schizophrenia.
FAU - Toyooka, Kazuhiko
AU  - Toyooka K
AD  - Department of Molecular Neurobiology, Brain Research Institute, Niigata 
      University Asahimachi-dori 1-757, Niigata 951-8585, Japan.
FAU - Asama, Koue
AU  - Asama K
FAU - Watanabe, Yuichiro
AU  - Watanabe Y
FAU - Muratake, Tatsuyuki
AU  - Muratake T
FAU - Takahashi, Makoto
AU  - Takahashi M
FAU - Someya, Toshiyuki
AU  - Someya T
FAU - Nawa, Hiroyuki
AU  - Nawa H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antipsychotic Agents/pharmacology/therapeutic use
MH  - Blood Platelets/metabolism
MH  - Brain-Derived Neurotrophic Factor/blood/*metabolism
MH  - Chronic Disease
MH  - Female
MH  - Haloperidol/pharmacology/therapeutic use
MH  - Humans
MH  - Male
MH  - Rats
MH  - Schizophrenia/drug therapy/*metabolism
EDAT- 2002/07/20 10:00
MHDA- 2002/10/09 04:00
CRDT- 2002/07/20 10:00
PHST- 2002/07/20 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/07/20 10:00 [entrez]
AID - S0165178102001270 [pii]
AID - 10.1016/s0165-1781(02)00127-0 [doi]
PST - ppublish
SO  - Psychiatry Res. 2002 Jul 31;110(3):249-57. doi: 10.1016/s0165-1781(02)00127-0.