PMID- 12127736
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20191106
IS  - 0166-445X (Print)
IS  - 0166-445X (Linking)
VI  - 59
IP  - 3-4
DP  - 2002 Sep 24
TI  - Biodegradation and enzymatic responses in the marine diatom Skeletonema costatum 
      upon exposure to 2,4-dichlorophenol.
PG  - 191-200
AB  - The biodegradation and responses of selected detoxification and antioxidant 
      enzymes in the marine diatom, Skeletonema costatum, upon exposure to sublethal 
      concentrations of 2,4-dichlorophenol (2,4-DCP) were investigated. Results show 
      that 2,4-DCP was readily metabolised, but bioaccumulation and adsorption were 
      negligible. Glutathione S-transferase, ascorbate peroxidase and superoxide 
      dismutase activities were increased markedly after exposure to 2,4-DCP for 96 h, 
      while no appreciable change in peroxidase activity was observed. The addition of 
      exogeneous glutathione to diatom culture enhanced the degradation of 2,4-DCP, and 
      promoted diatom growth. The inhibition of glutathione synthesis enhanced the 
      toxicity of 2,4-DCP. These results suggest that glutathione conjugation was one 
      of the principal mechanisms involved in the degradation of 2,4-DCP in this 
      diatom.
FAU - Yang, Shao
AU  - Yang S
AD  - Department of Biology and Chemistry, Centre for Coastal Pollution and 
      Conservation, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong 
      Kong Special Administrative Region, Hong Kong, China.
FAU - Wu, Rudolf S S
AU  - Wu RS
FAU - Kong, Richard Y C
AU  - Kong RY
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Aquat Toxicol
JT  - Aquatic toxicology (Amsterdam, Netherlands)
JID - 8500246
RN  - 0 (Anthelmintics)
RN  - 0 (Chlorophenols)
RN  - EC 1.11.1.- (Peroxidases)
RN  - EC 1.11.1.11 (Ascorbate Peroxidases)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - GAN16C9B8O (Glutathione)
RN  - IY9XDZ35W2 (Glucose)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Adsorption
MH  - Animals
MH  - Anthelmintics
MH  - Ascorbate Peroxidases
MH  - Biodegradation, Environmental
MH  - Chlorophenols/metabolism/pharmacokinetics/*toxicity
MH  - Diatoms/*drug effects/enzymology/growth & development/metabolism
MH  - Glucose/pharmacology
MH  - Glutathione/administration & dosage/*metabolism
MH  - Glutathione Transferase/metabolism
MH  - Peroxidases/metabolism
MH  - Superoxide Dismutase/metabolism
MH  - Tissue Distribution
EDAT- 2002/07/20 10:00
MHDA- 2002/12/10 04:00
CRDT- 2002/07/20 10:00
PHST- 2002/07/20 10:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/07/20 10:00 [entrez]
AID - S0166445X01002521 [pii]
AID - 10.1016/s0166-445x(01)00252-1 [doi]
PST - ppublish
SO  - Aquat Toxicol. 2002 Sep 24;59(3-4):191-200. doi: 10.1016/s0166-445x(01)00252-1.