PMID- 12127899
OWN - NLM
STAT- MEDLINE
DCOM- 20030226
LR  - 20190922
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 24
IP  - 4
DP  - 2002 Jul-Aug
TI  - Long-term effects of developmental exposure to zidovudine on exploratory behavior 
      and novelty discrimination in CD-1 mice.
PG  - 529-40
AB  - Long-term changes in exploratory, social and agonistic behavior have been 
      reported in rodents following developmental exposure to zidovudine (AZT), an 
      agent commonly administered to pregnant seropositive women and their neonates to 
      prevent HIV-1 transmission. The present study evaluates the effects of either 
      prenatal or prolonged AZT treatment on spatial and nonspatial novelty 
      discrimination in mice, using an open-field test with four objects, in which 
      responses to both spatial rearrangement of familiar objects and object novelty 
      are assessed. AZT (160 mg/kg) or Saline was given orally twice daily to pregnant 
      mice from gestational days (GD) 10 to 19 (Experiment 1) or from GD 10 to 
      lactation day 10 (Experiment 2). Offspring of both sexes were tested on postnatal 
      day (PND) 28, 45 or 70. Depending on treatment schedule, AZT altered different 
      behavioral responses, males being more affected than females. The prenatal 
      treatment (Experiment 1) reduced exploration of the objects at all ages 
      considered and increased wall and top rearing at ages 45 and 70. Following 
      prolonged treatment (Experiment 2), AZT offspring were markedly more active than 
      controls and displayed more wall rearing at age 70 while showing lower grooming 
      frequency at all ages. Both AZT and control mice failed to respond to object 
      rearrangement at adulthood, a discrepancy from previous data, which is discussed 
      in relation to perinatal stress effects.
FAU - Calamandrei, Gemma
AU  - Calamandrei G
AD  - Laboratory of Pathophysiology, Section of Comparative Psychology, Istituto 
      Superiore di Sanita, Viale Regina Elena 299, I-00161 Rome, Italy. 
      gemma.calamandrei@iss.it
FAU - Rufini, Ombretta
AU  - Rufini O
FAU - Valanzano, Angela
AU  - Valanzano A
FAU - Puopolo, Maria
AU  - Puopolo M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Anti-HIV Agents)
RN  - 4B9XT59T7S (Zidovudine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Anti-HIV Agents/*toxicity
MH  - Discrimination Learning/*drug effects
MH  - Exploratory Behavior/*drug effects
MH  - Female
MH  - Lactation
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Sex Factors
MH  - Zidovudine/*toxicity
EDAT- 2002/07/20 10:00
MHDA- 2003/02/27 04:00
CRDT- 2002/07/20 10:00
PHST- 2002/07/20 10:00 [pubmed]
PHST- 2003/02/27 04:00 [medline]
PHST- 2002/07/20 10:00 [entrez]
AID - S0892036202002349 [pii]
AID - 10.1016/s0892-0362(02)00234-9 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2002 Jul-Aug;24(4):529-40. doi: 
      10.1016/s0892-0362(02)00234-9.