PMID- 12131387
OWN - NLM
STAT- MEDLINE
DCOM- 20021213
LR  - 20190711
IS  - 0022-5282 (Print)
IS  - 0022-5282 (Linking)
VI  - 53
IP  - 1
DP  - 2002 Jul
TI  - Preliminary report on the safety of heparin for deep venous thrombosis 
      prophylaxis after severe head injury.
PG  - 38-42; discussion 43
AB  - BACKGROUND: Prophylaxis for venous thromboembolism (VTE) in head injured patients 
      has avoided heparin products because of concern for exacerbating intracranial 
      bleeding. The purpose of this study was to evaluate the safety of unfractionated 
      heparin (UFH) for VTE prophylaxis after traumatic brain injury. METHODS: We 
      retrospectively evaluated the early use of UFH in patients sustaining a severe 
      closed head injury (Abbreviated Injury Scale score > 3) from January 1, 2000, 
      through December 31, 2000. Two groups were formed on the basis of the timing of 
      UFH administration: within 72 hours of admission (Early group), or after the 
      third day of hospitalization (Late group), if at all. Intracranial bleeding 
      related to UFH administration was assessed by computed tomographic scan of the 
      head and/or clinical examination. RESULTS: Sixty-four of 76 patients with 
      intracranial blood on admission head computed tomographic scan fulfilled study 
      criteria. Seventy-three percent (n = 47) were in the Early group and 27% (n = 17) 
      were in the Late group. None of the Early group had an increase in intracranial 
      bleeding or deterioration on neurologic examination as a result of UFH 
      administration. However, there was no statistical difference in VTE events 
      between the two groups. CONCLUSION: Early use of UFH in the severe head injured 
      patient does not increase bleeding complications.
FAU - Kim, Joseph
AU  - Kim J
AD  - Department of Surgery, University of Cincinnati, Ohio, USA.
FAU - Gearhart, Michelle M
AU  - Gearhart MM
FAU - Zurick, Andrew
AU  - Zurick A
FAU - Zuccarello, Mario
AU  - Zuccarello M
FAU - James, Laura
AU  - James L
FAU - Luchette, Fred A
AU  - Luchette FA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Abbreviated Injury Scale
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Anticoagulants/adverse effects/*therapeutic use
MH  - Cerebral Hemorrhage/chemically induced/diagnosis
MH  - Comorbidity
MH  - Drug Monitoring
MH  - Head Injuries, Closed/*complications/diagnosis/therapy
MH  - Heparin/adverse effects/*therapeutic use
MH  - Humans
MH  - Middle Aged
MH  - Neurologic Examination
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Safety
MH  - Thromboembolism/*etiology/*prevention & control
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Trauma Centers
MH  - Treatment Outcome
MH  - Venous Thrombosis/*etiology/*prevention & control
EDAT- 2002/07/20 10:00
MHDA- 2002/12/17 04:00
CRDT- 2002/07/20 10:00
PHST- 2002/07/20 10:00 [pubmed]
PHST- 2002/12/17 04:00 [medline]
PHST- 2002/07/20 10:00 [entrez]
AID - 10.1097/00005373-200207000-00008 [doi]
PST - ppublish
SO  - J Trauma. 2002 Jul;53(1):38-42; discussion 43. doi: 
      10.1097/00005373-200207000-00008.