PMID- 12135230
OWN - NLM
STAT- MEDLINE
DCOM- 20030107
LR  - 20191210
IS  - 0344-5607 (Print)
IS  - 0344-5607 (Linking)
VI  - 25
IP  - 3
DP  - 2002 Jun
TI  - Postoperative modified stereotactic radiotherapy using a micro-multileaf 
      collimator in patients with malignant glioma.
PG  - 166-73
AB  - To achieve local control of malignant glioma, we designed a postoperative 
      stereotactic radiotherapy using a micro-multileaf collimator (micro-MLC). The 
      purpose of this study was to clarify the feasibility of this treatment. The 
      treatment was performed in six patients who met the following eligibility 
      criteria: (1) supratentorial tumor, (2) residual tumor volume < or = 40 cm3, and 
      (3) Karnofsky performance status > or = 70. The three planning target volumes 
      (PTVs), which consisted of restricted PTV (RPTV), intermediate PTV (IPTV), and 
      extended PTV (EPTV), defined as the residual tumor plus a 1 cm, 2 cm, and 3 cm 
      margins, respectively, and total dose delivery of 60-68 Gy, 52-60 Gy, and 44-52 
      Gy to the isocenters of RPTV, IPTV, and EPTV, respectively, in 4 Gy per fraction 
      at five fractions per week, were established. The beam arrangement and the 
      conformal blockade with a micro-MLC for the optimal treatment plan were designed. 
      The treatment plans showed the high dose conformation to EPTV, the appropriate 
      dose gradients in the three PTVs with the high dose homogeneity to RPTV, and the 
      tolerated dose to critical structures. Following the plans, treatment was 
      performed. The clinical findings more than 12 months after the treatment 
      supported its possible use. We conclude that this treatment is feasible at least 
      in selected patients.
FAU - Isaka, Toshihiko
AU  - Isaka T
AD  - Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular 
      Diseases, Japan. thc-1107@nifty.com
FAU - Nishiyama, Kinji
AU  - Nishiyama K
FAU - Nakagawa, Hidemitsu
AU  - Nakagawa H
FAU - Suzuki, Tsuyoshi
AU  - Suzuki T
FAU - Wada, Kouichi
AU  - Wada K
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Germany
TA  - Neurosurg Rev
JT  - Neurosurgical review
JID - 7908181
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/pathology/*radiotherapy/*surgery
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Glioma/pathology/*radiotherapy/*surgery
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Postoperative Care/*instrumentation/*methods
MH  - Stereotaxic Techniques/*instrumentation
MH  - Time Factors
EDAT- 2002/07/24 10:00
MHDA- 2003/01/08 04:00
CRDT- 2002/07/24 10:00
PHST- 2002/07/24 10:00 [pubmed]
PHST- 2003/01/08 04:00 [medline]
PHST- 2002/07/24 10:00 [entrez]
AID - 10.1007/s101430100185 [doi]
PST - ppublish
SO  - Neurosurg Rev. 2002 Jun;25(3):166-73. doi: 10.1007/s101430100185.